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25287-05-2

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25287-05-2 Usage

General Description

2-(4-amino-phenyl)-benzo[de]isoquinoline-1,3-dione, also known as BIDQ, is a chemical compound that belongs to the benzo[de]isoquinoline class. It consists of a benzene ring fused to a decahydroisoquinoline and a cyclic dione ring. BIDQ is known for its potential biological activities, including anti-inflammatory, anti-cancer, and anti-microbial properties. It has also been studied for its potential in treating neurological disorders, such as Alzheimer's disease. BIDQ is a versatile compound with potential applications in the pharmaceutical and medical industries.

Check Digit Verification of cas no

The CAS Registry Mumber 25287-05-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,5,2,8 and 7 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 25287-05:
(7*2)+(6*5)+(5*2)+(4*8)+(3*7)+(2*0)+(1*5)=112
112 % 10 = 2
So 25287-05-2 is a valid CAS Registry Number.
InChI:InChI=1/C18H12N2O2/c19-12-7-9-13(10-8-12)20-17(21)14-5-1-3-11-4-2-6-15(16(11)14)18(20)22/h1-10H,19H2

25287-05-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(4-aminophenyl)benzo[de]isoquinoline-1,3-dione

1.2 Other means of identification

Product number -
Other names 2-(2-CHLORO-4-IODOPHENYLAMINO)-3,4-DIFLUOROBENZOIC ACID

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:25287-05-2 SDS

25287-05-2Downstream Products

25287-05-2Relevant articles and documents

Toward intrinsically fluorescent proteomimetics: Fluorescent probe response to alpha helix structure of poly-γ-benzyl-l-glutamate

Hutt, Kenji,Hernandez, Randy,Heagy, Michael D.

, p. 5436 - 5438 (2006)

A fluorescent probe (1), developed for recognition of alpha helical secondary structure, shows a large fluorescence change upon titration with the synthetic protein PBLG. Compared to fluorophores of similar size and shape, 1 displayed the smallest dissoci

Modelling and Phenotypic Screening of NAP-6 and 10-Cl-BBQ, AhR Ligands Displaying Selective Breast Cancer Cytotoxicity in Vitro

Baker, Jennifer R.,Pollard, Brett L.,Lin, Andrew J. S.,Gilbert, Jayne,Paula, Stefan,Zhu, Xiao,Sakoff, Jennette A.,McCluskey, Adam

, p. 1499 - 1512 (2021/03/03)

To exploit the interaction of the aryl hydrocarbon receptor (AhR) pathway in developing breast-cancer-specific cytotoxic compounds, we examined the breast cancer selectivity and the docking pose of the AhR ligands (Z)-2-(2-aminophenyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione (NAP-6; 5) and 10-chloro-7H-benzo[de]benzo[4,5]imidazo[2,1-a]isoquinolin-7-one (10-Cl-BBQ; 6). While the breast cancer selectivity of 5 in vitro is known, we discuss the SAR around this lead and, by using phenotypic cell-line screening and the MTT assay, show for the first time that 6 also presents with breast cancer selectivity, notably in the triple-negative (TN) receptor breast cancer cell line MDA-MB-468, the ER+ breast cancer cell lines T47D, ZR-75-1 and the HER2+ breast cancer cell line SKBR3 (GI50 values of 0.098, 0.97, 0.13 and 0.21 μM, respectively). Indeed, 6 is 55 times more potent in MDA-MB-468 cells than normal MCF10A breast cells (GI50 of 0.098 vs 5.4 μM) and more than 130 times more potent than in cell lines derived from pancreas, brain and prostate (GI50 of 0.098 vs 10–13 μM). Molecular docking poses of 5 and 6 together with analogue synthesis and phenotypic screening show the importance of the naphthalene moiety, and an ortho-disposed substituent on the N-phenyl moiety for biological activity.

Sensor molecules based on naphthalimide derivatives and their synthesis and application

-

Paragraph 0026; 0027, (2018/11/03)

The invention discloses sensor molecules TN based on naphthalimide derivatives. The sensor molecules are C63H36N6O9 and employ naphthalimides as fluorescence signal reporter groups and three amide groups as hydrogen bond sites such that the molecules have

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