252872-74-5Relevant academic research and scientific papers
Synthesis and antiviral activities of novel N-alkoxy-arylsulfonamide-based HIV protease inhibitors
Sherrill, Ronald G.,Furfine, Eric S.,Hazen, Richard J.,Miller, John F.,Reynolds, David J.,Sammond, Douglas M.,Spaltenstein, Andrew,Wheelan, Pat,Wright, Lois L.
, p. 3560 - 3564 (2005)
A series of novel N-alkoxy-arylsulfonamide HIV protease inhibitors with low picomolar enzyme activity and single digit nanomolar antiviral activity is disclosed.
Sulfonamide inhibitors of aspartyl protease
-
, (2008/06/13)
The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and physicochemical
