252882-61-4

Basic information

• Product Name: SPIRO[INDOLINE-3,4'-PIPERIDIN]-2-ONE
• Synonyms: SPIRO[INDOLINE-3,4'-PIPERIDIN]-2-ONE;1,2-dihydrospiro[indole-3,4'-piperidine]-2-one;Spiro[3H-indole-3,4'-piperidin]-2(1H)-one;1,2-Dihydro-2-oxo-spiro[3H-indole-3,4'-piperidine];spiro[1H-indole-3,4'-piperidine]-2-one
• CAS NO: 252882-61-4
• Molecular Formula: C₁₂H₁₄N₂O
• Molecular Weight: 202.256
• Mol File: 252882-61-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 413.2±45.0 °C(Predicted)
• Appearance: /
• Density: 1.23±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 13.94±0.20(Predicted)
• CAS DataBase Reference: SPIRO[INDOLINE-3,4'-PIPERIDIN]-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: SPIRO[INDOLINE-3,4'-PIPERIDIN]-2-ONE(252882-61-4)
• EPA Substance Registry System: SPIRO[INDOLINE-3,4'-PIPERIDIN]-2-ONE(252882-61-4)

Safety Data

• Hazardous Substances Data: 252882-61-4(Hazardous Substances Data)

Usage

General Description

SPIRO[INDOLINE-3,4'-PIPERIDIN]-2-ONE, also known as spirooxindole, is a chemical compound that contains a spiro ring system. It is commonly used as a building block in the synthesis of various biologically active compounds, including pharmaceutical drugs and natural products. SPIRO[INDOLINE-3,4'-PIPERIDIN]-2-ONE has demonstrated potential for a wide range of therapeutic applications, including as an anticancer, antiviral, and antibacterial agent. The unique structural features of spirooxindole make it a valuable tool in medicinal chemistry for the development of new drugs with improved pharmacological properties. Additionally, spirooxindole derivatives have been found to exhibit diverse biological activities, making them promising candidates for further research and drug discovery efforts.

Upstream product

• 59-48-3 2-oxoindole 
• 1086063-19-5 1'-benzylspiro[indoline-3,4'-piperidin]-2-one 
• 252882-60-3 tert-butyl 2-oxo-1,2-dihydro-1'H-spiro[indole-3,4-piperidine]-1'-carboxylate 

Downstream Products

• 1086063-13-9 2-oxo-N-{2-(trifluoromethyl)benzyl}spiro(indoline-3,4'-piperidine)-1'-carboxamide 
• 1086061-32-6 1'-{2-(2-trifluoromethylphenoxy)acetyl}spiro(indole-3,4'-piperidine)-2(1H)-one 
• 1086061-36-0 1'-{2-(2-trifluoromethoxyphenoxy)acetyl}spiro(indole-3,4'-piperidine)-2(1H)-one 
• 1086063-09-3 1-cyclopropyl-1'-{2-(2-trifluoromethylphenoxy)acetyl}spiro(indole-3,4'-piperidine)-2-one 
• 1086062-98-7 1-methyl-1'-{2-(2-trifluoromethylphenoxy)acetyl}spiro(indole-3,4'-piperidine)-2-one 
• 1086061-34-8 1'-{2-(2-methylphenoxy)acetyl}spiro(indole-3,4'-piperidine)-2(1H)-one 
• 252882-60-3 tert-butyl 2-oxo-1,2-dihydro-1'H-spiro[indole-3,4-piperidine]-1'-carboxylate 
• 1086282-03-2 C₁₉H₂₁N₃O 

Relevant articles and documents

Discovery of 3,3′-Spiro[Azetidine]-2-oxo-indoline Derivatives as Fusion Inhibitors for Treatment of RSV Infection

A new series of 3,3′-spirocyclic-2-oxo-indoline derivatives was synthesized and evaluated against respiratory syncytial virus (RSV) in a cell-based assay and animal model. Extensive structure-activity relationship study led to a lead compound 14h, which e

SPIROINDALONES

The present invention relates to spiroindalone compounds useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.

FUSED AND SPIROCYCLE COMPOUNDS AND THE USE THEREOF

The invention relates to fused and spirocycle compounds of Formula (I), or a pharmaceutically acceptable salt, prodrug, or solvate thereof, wherein R1, R2, Q1-Q3, and Z are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula (I) to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.