252882-61-4

Basic information

• Product Name: SPIRO[INDOLINE-3,4'-PIPERIDIN]-2-ONE
• Synonyms: SPIRO[INDOLINE-3,4'-PIPERIDIN]-2-ONE;1,2-dihydrospiro[indole-3,4'-piperidine]-2-one;Spiro[3H-indole-3,4'-piperidin]-2(1H)-one;1,2-Dihydro-2-oxo-spiro[3H-indole-3,4'-piperidine];spiro[1H-indole-3,4'-piperidine]-2-one
• CAS NO: 252882-61-4
• Molecular Formula: C₁₂H₁₄N₂O
• Molecular Weight: 202.256
• Mol File: 252882-61-4.mol

Chemical Properties

• Boiling Point: 413.2±45.0 °C(Predicted)
• Appearance: /
• Density: 1.23±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 13.94±0.20(Predicted)
• CAS DataBase Reference: SPIRO[INDOLINE-3,4'-PIPERIDIN]-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: SPIRO[INDOLINE-3,4'-PIPERIDIN]-2-ONE(252882-61-4)
• EPA Substance Registry System: SPIRO[INDOLINE-3,4'-PIPERIDIN]-2-ONE(252882-61-4)

Safety Data

• Hazardous Substances Data: 252882-61-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
SPIRO[INDOLINE-3,4'-PIPERIDIN]-2-ONE is used as a key intermediate in the synthesis of biologically active compounds for the development of new pharmaceutical drugs. Its unique spiro ring system contributes to the creation of molecules with improved pharmacological properties, making it a valuable component in drug discovery and design.
Used in Anticancer Applications:
In the field of oncology, SPIRO[INDOLINE-3,4'-PIPERIDIN]-2-ONE is utilized as a potential anticancer agent, targeting a variety of cancer types. Its structural features allow for the modulation of multiple signaling pathways involved in cancer progression, thereby exhibiting inhibitory effects on tumor growth.
Used in Antiviral and Antibacterial Applications:
SPIRO[INDOLINE-3,4'-PIPERIDIN]-2-ONE also serves as a precursor for the development of antiviral and antibacterial agents, leveraging its ability to interfere with the life cycles of viruses and bacteria, thus offering potential therapeutic benefits in the treatment of infectious diseases.
Used in Drug Discovery Research:
SPIRO[INDOLINE-3,4'-PIPERIDIN]-2-ONE is employed as a research tool in medicinal chemistry for exploring its diverse biological activities. Its derivatives are studied for their potential to address unmet needs in therapeutic areas, making SPIRO[INDOLINE-3,4'-PIPERIDIN]-2-ONE a promising candidate for further investigation and development in the pharmaceutical sector.

Upstream product

• 59-48-3 2-oxoindole 
• 1086063-19-5 1'-benzylspiro[indoline-3,4'-piperidin]-2-one 
• 252882-60-3 tert-butyl 2-oxo-1,2-dihydro-1'H-spiro[indole-3,4-piperidine]-1'-carboxylate 

Downstream Products

• 1086063-13-9 2-oxo-N-{2-(trifluoromethyl)benzyl}spiro(indoline-3,4'-piperidine)-1'-carboxamide 
• 1086061-32-6 1'-{2-(2-trifluoromethylphenoxy)acetyl}spiro(indole-3,4'-piperidine)-2(1H)-one 
• 1086061-36-0 1'-{2-(2-trifluoromethoxyphenoxy)acetyl}spiro(indole-3,4'-piperidine)-2(1H)-one 
• 1086063-09-3 1-cyclopropyl-1'-{2-(2-trifluoromethylphenoxy)acetyl}spiro(indole-3,4'-piperidine)-2-one 
• 1086062-98-7 1-methyl-1'-{2-(2-trifluoromethylphenoxy)acetyl}spiro(indole-3,4'-piperidine)-2-one 
• 1086061-34-8 1'-{2-(2-methylphenoxy)acetyl}spiro(indole-3,4'-piperidine)-2(1H)-one 
• 252882-60-3 tert-butyl 2-oxo-1,2-dihydro-1'H-spiro[indole-3,4-piperidine]-1'-carboxylate 
• 1086282-03-2 C₁₉H₂₁N₃O 

Relevant articles and documents

Discovery of 3,3′-Spiro[Azetidine]-2-oxo-indoline Derivatives as Fusion Inhibitors for Treatment of RSV Infection

A new series of 3,3′-spirocyclic-2-oxo-indoline derivatives was synthesized and evaluated against respiratory syncytial virus (RSV) in a cell-based assay and animal model. Extensive structure-activity relationship study led to a lead compound 14h, which e

RSV ANTIVIRAL COMPOUNDS

Inhibitors of RSV replication of formula RI including stereochemically isomeric forms, and salts or solvates thereof, wherein R22, W, Q, V, Z p,s,and Het have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other RSV inhibitors, in RSV therapy.

SPIROINDALONES

The present invention relates to spiroindalone compounds useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.

NOVEL SPIROOXYINDOLE COMPOUNDS AND DRUGS CONTAINING SAME

A Spiro oxindole compound represented by formula (1) of the present invention or salt thereof, or their solvate shows a superior inhibitory effect of 11β-hydroxysteroid dehydrogenasel, and is useful as an agent for preventing or treating a disease that involves 11β-hydroxysteroid dehydrogenasel (in particular, diabetes, insulin resistance, diabetes complication, obesity, dyslipidemia, hypertension, fatty liver, or metabolic syndrome).

FUSED AND SPIROCYCLE COMPOUNDS AND THE USE THEREOF

The invention relates to fused and spirocycle compounds of Formula (I), or a pharmaceutically acceptable salt, prodrug, or solvate thereof, wherein R1, R2, Q1-Q3, and Z are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula (I) to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.

Inhibitors of prenyl-protein transferase

The present invention is directed to conformationally constrained compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.