252882-60-3

Basic information

• Product Name: 1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER
• Synonyms: 1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER;1'-BOC-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE];tert-butyl 2-oxospiro[indoline-3.4-piperidine]-1-carboxylate;1,1-DiMethylethyl 1,2-dihydro-2-oxospiro[3H-indole-3,4'-piperidine]-1'-carboxylate;1,1-DiMethylethyl 2-oxo-1,2-dihydro-1'H-spiro[indole-3,4'-piperidine]-1'-carboxylate;Spiro[3H-indole-3,4'-piperidine]-1'-carboxylic acid, 1,2-dihydro-2-oxo-, 1,1-diMethylethyl ester;tert-butyl 2-oxo-1,2-dihydrospiro[indole-3,4'- piperidine]-1'-carboxylate;Spiro[indole-3,4'-piperidin]-2(1H)-one,N1'-BOCprotected
• CAS NO: 252882-60-3
• Molecular Formula: C₁₇H₂₂N₂O₃
• Molecular Weight: 302.38
• Mol File: 252882-60-3.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 475.6 °C at 760 mmHg
• Flash Point: 241.4 °C
• Appearance: /
• Density: 1.22±0.1 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: 2-8°C
• PKA: 13.83±0.20(Predicted)
• CAS DataBase Reference: 1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER(252882-60-3)
• EPA Substance Registry System: 1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER(252882-60-3)

Safety Data

• Hazardous Substances Data: 252882-60-3(Hazardous Substances Data)

Usage

General Description

1,2-Dihydro-2-oxo-spiro[3H-indole-3,4'-piperidine]-1'-carboxylic acid 1,1-dimethylethyl ester is a chemical compound with a complex and specific molecular structure. It is a ester derivative with potential biological activity and is often used in pharmaceutical research and development. 1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER is known for its spirocyclic structure, which gives it unique properties and potential therapeutic applications. Its ability to interact with specific biological targets makes it a valuable tool in drug discovery and development. Additionally, the 1,1-dimethylethyl ester group contributes to the compound's stability and makes it suitable for various applications in the pharmaceutical and chemical industries.

Upstream product

• 1151786-48-9 1-benzyl-1'-(tert-butoxycarbonyl)-5-fluoro-2,3-dihydrospiro[(2-oxo)-indole-3,4'-piperidine] 
• 615-36-1 2-bromoaniline 
• 84358-13-4 N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid 
• 293744-31-7 tert-butyl 4-{[(benzyl)(2-bromophenyl)amino]carbonyl}piperidine-1-carboxylate 
• 293744-26-0 tert-butyl 4-{[(2-bromophenyl)amino]carbonyl}piperidine-1-carboxylate 
• 1086063-19-5 1'-benzylspiro[indoline-3,4'-piperidin]-2-one 
• 252882-61-4 spiro[indoline-3,4'-piperidin]-2-one 
• 24424-99-5 di-tert-butyl dicarbonate 
• 293744-34-0 tert-butyl 1-benzyl-1,2-dihydro-2-oxospiro[3H-indole-3,4'-piperidine]-1'-carboxylate 
• 59-48-3 2-oxoindole 
• 118753-70-1 N-(tert-butyloxycarbonyl)bis(2-chloroethyl)amine 

Downstream Products

• 1086282-13-4 tert-butyl 1-biphenyl-4-yl-2'-[methoxy(oxo)acetyl]-2-oxo-1,2-dihydro-1'H-spiro[indole-3,4'-piperidine]-1'-carboxylate 
• 1086280-00-3 1-biphenyl-4-yl-1'-[(1-methyl-1H-imidazol-2-yl)methyl]spiro[indole-3,4'-piperidin]-2(1H)-one 
• 293744-34-0 tert-butyl 1-benzyl-1,2-dihydro-2-oxospiro[3H-indole-3,4'-piperidine]-1'-carboxylate 
• 916445-11-9 1-benzyl-spiro[indoline-3,4'-piperidin]-2-one 
• 1215121-49-5 1,3-dihydro-1-phenyl-2H-indol-2-one 
• 1086282-02-1 C₂₄H₂₂N₂O 
• 1086280-55-8 C₂HF₃O₂*C₃₀H₂₈N₄O 
• 1086280-04-7 1-(biphenyl-4-yl)-1'-[(3-methylpyridin-2-yl)methyl]spiro[indole-3,4'-piperidin]-2(1H)-one trifluoroacetate 
• 1086280-01-4 C₂HF₃O₂*C₂₉H₂₈N₄O 
• 1086280-71-8 C₂HF₃O₂*C₂₉H₂₈N₄O₂ 
• 1086280-65-0 C₂HF₃O₂*C₂₅H₂₈N₄O 

Relevant articles and documents

PYRIDYL PIPERIDINES

The invention provides novel substituted pyridyl piperidine compounds according to Formula (I) which are Wnt pathway inhibitors, their manufacture and use for the treatment of hyperproliferative diseases such as cancer, inflammatory or degenerative diseases.

1,3,8-triazaspiro[4.5]decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia

The discovery of 1,3,8-triazaspiro[4.5]decane-2,4-diones (spirohydantoins) as a structural class of pan-inhibitors of the prolyl hydroxylase (PHD) family of enzymes for the treatment of anemia is described. The initial hit class, spirooxindoles, was identified through affinity selection mass spectrometry (AS-MS) and optimized for PHD2 inhibition and optimal PK/PD profile (short-acting PHDi inhibitors). 1,3,8-Triazaspiro[4.5]decane-2,4-diones (spirohydantoins) were optimized as an advanced lead class derived from the original spiroindole hit. A new set of general conditions for C-N coupling, developed using a high-throughput experimentation (HTE) technique, enabled a full SAR analysis of the spirohydantoins. This rapid and directed SAR exploration has resulted in the first reported examples of hydantoin derivatives with good PK in preclinical species. Potassium channel off-target activity (hERG) was successfully eliminated through the systematic introduction of acidic functionality to the molecular structure. Undesired upregulation of alanine aminotransferese (ALT) liver enzymes was mitigated and a robust on-/off-target margin was achieved. Spirohydantoins represent a class of highly efficacious, short-acting PHD1-3 inhibitors causing a robust erythropoietin (EPO) upregulation in vivo in multiple preclinical species. This profile deems spirohydantoins as attractive short-acting PHDi inhibitors with the potential for treatment of anemia.

SPIROINDALONES

The present invention relates to spiroindalone compounds useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.