25290-13-5

Basic information

• Product Name: 1-(1-Hydroxycyclohexyl)acetone
• Synonyms: 1-(1-Hydroxycyclohexyl)-2-propanone;1-(1-Hydroxycyclohexyl)acetone
• CAS NO: 25290-13-5
• Molecular Formula: C₉H₁₆O₂
• Molecular Weight: 156.2221
• Mol File: 25290-13-5.mol
• Article Data: 3

Chemical Properties

• Melting Point: 162-163 °C
• Boiling Point: 252.8°Cat760mmHg
• Flash Point: 104.3°C
• Appearance: /
• Density: 1.02g/cm³
• Vapor Pressure: 0.00293mmHg at 25°C
• Refractive Index: 1.475
• PKA: 14.57±0.20(Predicted)
• CAS DataBase Reference: 1-(1-Hydroxycyclohexyl)acetone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1-Hydroxycyclohexyl)acetone(25290-13-5)
• EPA Substance Registry System: 1-(1-Hydroxycyclohexyl)acetone(25290-13-5)

Safety Data

• Hazardous Substances Data: 25290-13-5(Hazardous Substances Data)

Usage

General Description

1-(1-Hydroxycyclohexyl)acetone is a chemical compound with the molecular formula C10H18O2. It is a colorless liquid with a faint odor, and it is commonly used as a flavoring agent in the food industry. 1-(1-Hydroxycyclohexyl)acetone is also used in the production of perfumes and fragrances due to its pleasant scent. Additionally, it has potential applications in the pharmaceutical and cosmetic industries. However, it is important to handle this chemical with care, as it may cause irritation to the skin and eyes upon contact. Overall, 1-(1-Hydroxycyclohexyl)acetone has various uses in different industries and is a versatile compound with unique properties.

InChI:InChI=1/C9H16O2/c1-8(10)7-9(11)5-3-2-4-6-9/h11H,2-7H2,1H3

Upstream product

• 1833-53-0 2-(Trimethylsilyloxy)propene 
• 108-94-1 cyclohexanone 
• 1123-34-8 1-allyl-1-cyclohexanol 
• 67-64-1 acetone 
• 14230-31-0 1-triethylstannanyl-propan-2-one 

Downstream Products

• 119582-57-9 1-(1-Trimethylsilanyloxy-cyclohexyl)-propan-2-one 

Relevant articles and documents

Cyclic Ether Synthesis via Palladium-Catalyzed Directed Dehydrogenative Annulation at Unactivated Terminal Positions

Here, a palladium-catalyzed functionalization of unactivated sp3 C-H bonds with internal alcohol nucleophiles is described. Directed by an oxime-masked alcohol, annulation chemoselectively occurs at the β position, leading to a range of aliphatic cyclic ethers with four- to seven-membered rings. Tethered primary, secondary, and tertiary free hydroxyl groups can all react to give the corresponding cyclized products. In addition, benzyl and silyl protected alcohols can also be directly coupled. An sp3 C-H activation/intramolecular SN2 pathway was proposed.

The boron-mediated ketone-ketone aldol reaction

The first examples of the directed, boron-mediated aldol reaction between different ketones are presented. Transformation of a variety of ketones to their corresponding boron enolates with Chx2BCl/Et3N, followed by reaction with acceptor ketones in diethyl ether, and oxidation of the resultant boron aldolate (H2O2, MeOH/pH 7 buffer), provided the aldol addition products. The reaction was most facile when cyclic ketones were used, with the highest yields obtained for the reaction of boron enolates with cyclohexanone as the acceptor.