252947-38-9

Upstream product

• 129368-70-3 (6-bromohexyloxy)-tert-butyldimethylsilane 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 4286-55-9 1-bromo-6-hexanol 
• 209325-02-0 7-Methoxy-3-(4-methoxyphenyl)-3-methylthiochroman-4-one 
• 119837-87-5 8-(t-Butyldimethylsilyloxy)-1-octyne 

Downstream Products

• 344466-23-5 tert-butyl-{8-[7-methoxy-3-(4-methoxy-phenyl)-3-methyl-thiochroman-4-yl]-oct-7-ynyloxy}-dimethyl-silane 

Relevant academic research and scientific papers

Discovery of thiochroman and chroman derivatives as pure antiestrogens and their structure-activity relationship

In order to develop pure antiestrogens, a series of 7-hydroxy-3-(4-hydroxyphenyl)-3-methylchroman and 7-hydroxy-3-(4-hydroxyphenyl)-3-methylthiochroman derivatives with sulfoxide containing side chains at the 4-position were designed, synthesized, and eva

Metal salts of 3-methyl-chromane or thiochromane derivatives

The present invention relates to metal salts of 3-methyl-chromane or thiochromane derivatives, stereoisomers or hydrates thereof, and an anti-estrogenic pharmaceutical composition which comprises the above compound as an active component and exhibits a hi

Benzopyran or thiobenzopyran derivatives

The present invention provides novel benzopyran compounds, pharmaceutically acceptable salts thereof and stereoisomers thereof where the benzopyran compounds of the invention are compounds according to Formula I: The present invention further provides pharmaceutical compositions which possess anti-estrogenic activity and comprise at least one benzopyran compound of the invention and a method of treating breast cancer by administration of an effective amount of a benzopyran compound provided by the present invention.