252954-41-9Relevant academic research and scientific papers
Synthesis of bicyclic cyclopropylamines by intramolecular cyclopropanation of N-allylamino acid dimethylamides
Cao, Bin,Xiao, Dong,Joullié, Madeleine M.
, p. 1799 - 1801 (2008/02/11)
(formula presented) Cyclopropylamines and substituted cyclopropylamines are important building blocks or substituents in a variety of biologically active compounds. Here, we report the facile syntheses of cyclopropylamines by Ti(II)-mediated intramolecular coupling of a terminal olefinic moiety and the N,N-dimethylcarboxamide moiety of amino acid derivatives. The products have novel and strained bicyclic structures. The yields were good (78-83%) for all three substrates with diastereomeric ratios of about 3:1.
