25297-16-9

Basic information

• Product Name: Benzeneacetic acid, 2-bromo-4-methyl-
• Synonyms: Benzeneacetic acid, 2-bromo-4-methyl-
• CAS NO: 25297-16-9
• Molecular Formula: C₉H₉BrO₂
• Molecular Weight: 229.07
• Mol File: 25297-16-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 305.8±27.0 °C(Predicted)
• Appearance: /
• Density: 1.557±0.06 g/cm3(Predicted)
• PKA: 2.49±0.10(Predicted)
• CAS DataBase Reference: Benzeneacetic acid, 2-bromo-4-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetic acid, 2-bromo-4-methyl-(25297-16-9)
• EPA Substance Registry System: Benzeneacetic acid, 2-bromo-4-methyl-(25297-16-9)

Safety Data

• Hazardous Substances Data: 25297-16-9(Hazardous Substances Data)

Upstream product

• 122-00-9 para-methylacetophenone 
• 104-87-0 4-methyl-benzaldehyde 
• 4815-10-5 2-hydroxy-2-(4-methylphenyl)acetonitrile 
• 622-47-9 4-tolylacetic acid 
• 18584-20-8 4-methylmandelic acid 

Downstream Products

• 530091-80-6 benzyl 2-bromo-2-(p-tolyl)acetate 
• 77053-52-2 methyl bromo(4-methylphenyl)acetate 
• 15674-78-9 (+/-)-α-bromo-p-tolylacetic acid ethyl ester 

Relevant articles and documents

Catalytic Asymmetric Conjugate Addition and Sulfenylation of Diarylthiazolidin-2,4-diones

This work reports the first application of diarylthiazolidin-2,4-diones as nucleophiles in asymmetric catalysis. By utilizing chiral amino acid-based (thio)urea-tertiary amines as the catalysts, we successively established asymmetric conjugate addition to nitroolefins and sulfenylation to N-(sulfanyl)-succinimides of diarylthiazolidin-2,4-diones. Two series of biologically important 5-aryl-5-substituted thiazolidin-2,4-diones were obtained with high enantio- and diastereoselectivities (up to >99% ee and >19:1 dr). The enantioenriched adducts were found to show satisfactory anticancer activities against three different cancer cell lines using the MTT assay. All of these successes depended on the development of a general and expedient synthetic strategy to provide diverse 5H-thiazolidin-2,4-diones.