18584-20-8

Basic information

• Product Name: HYDROXY-P-TOLYL-ACETIC ACID
• Synonyms: P-METHYL MANDELIC ACID;4-METHYLMALDELIC ACID;HYDROXY-P-TOLYL-ACETIC ACID;p-Methylphenylhydroxyacetic ac;Nsc126594;Benzeneacetic acid, a-hydroxy-4-Methyl-;Hydroxy(4-methylphenyl)acetic acid, 4-[Carboxy(hydroxy)methyl]toluene;alpha-Hydroxy-4-methylphenyl-acetic acid
• CAS NO: 18584-20-8
• Molecular Formula: C₉H₁₀O₃
• Molecular Weight: 166.17
• Product Categories: pharmacetical
• Mol File: 18584-20-8.mol
• Article Data: 46

Chemical Properties

• Melting Point: 145-146 °C
• Boiling Point: 336.4°Cat760mmHg
• Flash Point: 171.4°C
• Appearance: /
• Density: 1.264g/cm³
• Vapor Pressure: 4.41E-05mmHg at 25°C
• Refractive Index: 1.579
• PKA: 3.55±0.10(Predicted)
• CAS DataBase Reference: HYDROXY-P-TOLYL-ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: HYDROXY-P-TOLYL-ACETIC ACID(18584-20-8)
• EPA Substance Registry System: HYDROXY-P-TOLYL-ACETIC ACID(18584-20-8)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 18584-20-8(Hazardous Substances Data)

Usage

General Description

HYDROXY-P-TOLYL-ACETIC ACID is a chemical compound with the molecular formula C9H10O3. It is a white, crystalline solid that is soluble in organic solvents and slightly soluble in water. HYDROXY-P-TOLYL-ACETIC ACID is commonly used in the pharmaceutical industry as a raw material for the production of various drugs and medicines. It is also utilized in the synthesis of other organic compounds and as an intermediate in the manufacturing of perfumes and fragrances. Additionally, HYDROXY-P-TOLYL-ACETIC ACID has been studied for its potential anti-inflammatory and analgesic properties, making it an important compound in the development of new pharmaceutical products.

InChI:InChI=1/C9H10O3/c1-6-2-4-7(5-3-6)8(10)9(11)12/h2-5,8,10H,1H3,(H,11,12)

Upstream product

• 412014-15-4 diethyl 2-hydroxy-2-(4-methylphenyl)propane-1,3-dioate 
• 18584-23-1 hydroxy-p-tolyl-acetic acid ethyl ester 
• 17936-73-1 2,2,2-trichloro-1-p-tolyl-ethanol 
• 4815-10-5 2-hydroxy-2-(4-methylphenyl)acetonitrile 
• 98-88-4 benzoyl chloride 
• 99-94-5 p-Toluic acid 
• 104-87-0 4-methyl-benzaldehyde 
• 7163-50-0 (4-methylphenyl)(oxo)acetic acid 
• 34966-53-5 methyl 4-methylphenylglyoxylate 
• 106-38-7 para-bromotoluene 
• 122-00-9 para-methylacetophenone 
• 1075-47-4 4-methylphenylglyoxal 
• 179914-05-7 (R)-1-(4-methylphenyl)-1,2-ethanediol 
• 128042-08-0 (2,2,2-Tribromo-1-p-tolyl-ethyl)-carbamic acid methyl ester 

Downstream Products

• 13305-13-0 methyl (+/-)-α-hydroxy-α-(4-methylphenyl)acetate 
• 18584-20-8 (R)-para-methylmandelic acid 
• 37135-54-9 2,2-diethyl-5-p-tolyl-[1,3,2]dioxasilolan-4-one 
• 91143-62-3 (+)-p-methyl-O-acetylmandelic acid 
• 18584-20-8 (-)-p-methylmandelic acid 
• 7163-50-0 (4-methylphenyl)(oxo)acetic acid 
• 18584-20-8 (S)-2-hydroxy-2-(p-tolyl)acetic acid 
• 887641-38-5 benzyl 2-hydroxy-2-(p-tolyl)acetate 
• 1476804-80-4 C₂₃H₁₈N₂O₂ 
• 1476803-97-0 C₂₃H₂₀N₂O₃ 
• 1882-56-0 2-(4-methylphenyl)-2-phenylacetic acid 
• 101096-04-2 (4-chloro-phenyl)-p-tolyl-acetic acid 
• 104-87-0 4-methyl-benzaldehyde 
• 10295-44-0 2-hydroxy-N-phenyl-2-(p-tolyl)acetamide 

Relevant articles and documents

Reductive Coupling of Carbon Dioxide and an Aldehyde Mediated by a Copper(I) Complex toward the Synthesis of α-Hydroxycarboxylic Acids

Copper-mediated reductive coupling between CO2 and an aldehyde to form α-hydroxycarboxylic acid was achieved using silylborane as a reductant. CO2 cleanly inserted into a copper-carbon bond that was formed by the reaction between a silylcopper-NHC complex

The Synthesis of Chiral α-Aryl α-Hydroxy Carboxylic Acids via RuPHOX-Ru Catalyzed Asymmetric Hydrogenation

A ruthenocenyl phosphino-oxazoline-ruthenium complex (RuPHOX?Ru) catalyzed asymmetric hydrogenation of α-aryl keto acids has been successfully developed, affording the corresponding chiral α-aryl α-hydroxy carboxylic acids in high yields and with up to 97% ee. The reaction could be performed on a gram scale with a relatively low catalyst loading (up to 5000 S/C) and the resulting products can be transformed to several chiral building blocks, biologically active compounds and chiral drugs. (Figure presented.).

Asymmetric hydrogenation reaction of alpha-ketoacids compound

The invention relates to the technical field of organic chemistry, especially to an asymmetric hydrogenation reaction of an alpha-ketoacids compound. The asymmetric hydrogenation reaction comprises a scheme shown in the description. In the scheme, R1 is phenyl, substituted phenyl, naphthyl, substituted naphthyl, C1-C6 alkyl, or aralkyl; a substituent group is C1-C6 alkyl, C1-C6 alkoxy, or halogen; and the number of the substituent group is 1-3. In the scheme, M is a chiral spiro-pyridylamino phosphine ligand iridium complex having a structure shown in the description. In the structure, R is hydrogen, 3-methyl, 4-tBu, or 6-methyl.