84807-09-0

Basic information

• Product Name: 4-(Piperazino)indole
• Synonyms: 4-(1-piperazinyl)-1h-indol;4-(1-PIPERAZINYL)-1H-INDOLE;4-PIPERAZINO-1H-INDOLE;4-(Piperazino)indole;1H-Indole, 4-(1-piperazinyl)-;1-(4-Indolyl)piperazine;4-(1-Piperazinyl)indole
• CAS NO: 84807-09-0
• Molecular Formula: C₁₂H₁₅N₃
• Molecular Weight: 201.27
• Product Categories: Indole Derivatives
• Mol File: 84807-09-0.mol
• Article Data: 11

Chemical Properties

• Melting Point: 204-206°C
• Boiling Point: 421.5 °C at 760 mmHg
• Flash Point: 208.7 °C
• Appearance: /Solid
• Density: 1.182 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.65
• Storage Temp.: -20°C Freezer
• PKA: 18.78±0.30(Predicted)
• CAS DataBase Reference: 4-(Piperazino)indole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(Piperazino)indole(84807-09-0)
• EPA Substance Registry System: 4-(Piperazino)indole(84807-09-0)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• RTECS: NM1302400
• Hazardous Substances Data: 84807-09-0(Hazardous Substances Data)

Usage

Chemical Properties

Brown Solid

Uses

4-(1-Piperazinyl)-1H-indole Dihydrochloride (cas# 84807-09-0) is a compound useful in organic synthesis.

InChI:InChI=1/C12H15N3/c1-2-11-10(4-5-14-11)12(3-1)15-8-6-13-7-9-15/h1-5,13-14H,6-9H2

Upstream product

• 5192-23-4 4-amino-1H-indole 
• 615-43-0 2-iodophenylamine 
• 1562567-12-7 N-(tert-butyl)-2-iodoaniline 
• 821-48-7 bis-(2-chloroethyl)amine hydrochloride 
• 252978-89-5 4-(1H-indol-4-yl)-piperazine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 349671-61-0 4-{4-[2-(2,6-Dimethyl-phenoxy)-ethyl]-piperazin-1-yl}-1H-indole 
• 349671-27-8 4-{4-[3-(2-Chloro-phenoxy)-propyl]-piperazin-1-yl}-1H-indole 
• 349671-91-6 1-[2-chloro-4-fluorophenylthiomethylcarbonyl]-4-[1H-indol-4-yl]piperazine 
• 349671-28-9 4-{4-[3-(2-Chloro-phenylsulfanyl)-propyl]-piperazin-1-yl}-1H-indole 
• 220383-03-9 1-[N-(2-nitrophenyl)-2-aminoethyl]-4-(4-indolyl)-piperazine 
• 882256-55-5 4-(1H-indol-4-yl)-N-phenylpiperazine-1-carboxamide 

Relevant articles and documents

Synthesis of C4-Aminated Indoles via a Catellani and Retro-Diels-Alder Strategy

Highly functionalized 4-aminoindoles were synthesized via the three-component cross-coupling of o-iodoaniline, N-benzoyloxyamines, and norbornadiene. The Catellani and retro-Diels-Alder strategy was used in this domino process. o-Iodoaniline, with electron-donating and sterically hindered protecting groups, made the reaction selective toward o-C-H amination. On the basis of density functional theory calculations, the intramolecular Buchwald coupling of this reaction underwent a dearomatization and a 1,3-palladium migration process. The reasons for the control of the chemical selectivity by the protecting groups are given. Moreover, synthetic applications toward 4-piperazinylindole and a GOT1 inhibitor were realized.

AROMATIC HETEROCYCLIC DERIVATIVES AND PHARMACEUTICAL APPLICATIONS THEREOF

Provided herein are aromatic heterocyclic derivatives or a stereoisomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof used for treating Alzheimer's disease. Also provided herein are pharmaceutica

Deprotection of N-BOC compounds

Organic compounds having nitrogen atoms protected with t-butoxycarbonyl are effectively deprotected by heating in a fluorinated alcohol solution.