252987-07-8

Basic information

• Product Name: (3-(benzyloxy)-5-{[(4-methoxybenzyl)oxy]methyl}-4-pyridinyl)methanol
• Synonyms: (3-(benzyloxy)-5-{[(4-methoxybenzyl)oxy]methyl}-4-pyridinyl)methanol
• CAS NO: 252987-07-8
• Molecular Weight: 365.429
• Mol File: 252987-07-8.mol

Chemical Properties

• CAS DataBase Reference: (3-(benzyloxy)-5-{[(4-methoxybenzyl)oxy]methyl}-4-pyridinyl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (3-(benzyloxy)-5-{[(4-methoxybenzyl)oxy]methyl}-4-pyridinyl)methanol(252987-07-8)
• EPA Substance Registry System: (3-(benzyloxy)-5-{[(4-methoxybenzyl)oxy]methyl}-4-pyridinyl)methanol(252987-07-8)

Safety Data

• Hazardous Substances Data: 252987-07-8(Hazardous Substances Data)

Upstream product

• 3204-68-0 benzyldimethylphenylammonium chloride 
• 252987-06-7 4-(hydroxymethyl)-5-{[(4-methoxybenzyl)oxy]methyl}-3-pyridinol 
• 1136-52-3 (2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanol 
• 252987-03-4 5-{[(4-methoxybenzyl)oxy]methyl}-2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridine 
• 280762-77-8 5-((4-methoxybenzyloxy)methyl)-2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridine 7-oxide 
• 280762-79-0 5-((4-methoxybenzyloxy)methyl)-2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridine-8-carboxylic acid 
• 252987-04-5 (5-{[(4-methoxybenzyl)oxy]methyl}-2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridin-8-yl)methanol 
• 280762-58-5 5-{[(4-methoxybenzyl)oxy]methyl}-2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridine-8-carbaldehyde 
• 252987-05-6 5-{[(4-methoxybenzyl)oxy]methyl}-2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridine 
• 824-94-2 p-methoxybenzyl chloride 

Downstream Products

• 252987-08-9 [5-(benzyloxy)-4-(chloromethyl)-3-pyridinyl]methanol 
• 280762-61-0 tert-butyl-(4S)-4-[(E:Z)-2-(5-(benzyloxy)-4-{(2S)-2-[bis(tert-butoxycarbonyl)amio]-3-methoxy-3-oxopropyl}-3-pyridinyl)ethenyl]-2-oxo-1,3-oxazolidine-3-carboxylate 
• 280762-62-1 methyl-(2S)-3-(3-(benzyloxy)-5-{(E:Z,3S)-3-[(tert-butoxycarbonyl)amino]-4-hydroxy-1-butenyl}-4-pyridinyl)-2-[bis(tert-butoxycarbonyl)amino]propanoate 
• 280762-60-9 (4S)-4-[(E:Z)-2-(5-(benzyloxy)-4-{[(2S,5R)-5-isopropyl-3,6-dimethoxy-2,5-dihydro-2-pyrazinyl]methyl}-3-pyridinyl)ethenyl]-1,3-oxazolidin-2-one 
• 252987-10-3 (+)-5-(benzyloxy)-4-{[(2S,5R)-5-isopropyl-3,6-dimethoxy-2,5-dihydro-2-pyrazinyl]methyl}nicotinaldehyde 
• 280762-59-6 3-benzyloxy-4-chloromethyl-5-(4-methoxy-benzyloxymethyl)-pyridine 

Relevant articles and documents

Transformation of vitamin B6 to (+)-deoxypyridinoline, a useful biochemical marker for diagnosis of bone diseases

A versatile chiral synthesis of the cross-link (+)-deoxypyridinoline (Dpd, 2) was achieved starting from vitamin B6 (7). The key steps in the synthesis of (+)-2 are transformation of B6 (7) to the chloride (3d) and construction of three α-amino acid chains by utilizing (R)-(-)-Schollkopf's reagent (4), Wittig reagent (R)-(-)-5, and iodide (5)-(-)-6. (+)-Dpd (2) is a degradation product of bone collagen and has been found to be a useful marker for diagnosis of osteoporosis and other metabolic bone diseases. (C) 2000 Elsevier Science Ltd.

Versatile synthesis of (+)-deoxypyridinoline, a biochemical marker for diagnosis of osteoporosis

A versatile chiral synthesis of the bone collagen cross-link, (+)-deoxypyridinoline (Dpd, 1) was described starting from a 3-hydroxypyridine derivative (2) via sequential introduction of three amino acid chains followed by hydrolysis. The key synthon 2, was prepared from vitamin B6 (6).