25299-18-7

Upstream product

• 606-23-5 1H-indene-1,3(2H)-dione 
• 90-02-8 salicylaldehyde 
• 779-84-0 N-phenylsalicylaldimine 

Relevant academic research and scientific papers

The Quest of Excited-State Intramolecular Proton Transfer via Eight-Membered Ring π-Conjugated Hydrogen Bonding System

Searching for eight-membered ring π-conjugated hydrogen bonding (8-MR H-bonding) systems with excited-state intramolecular proton transfer (ESIPT) property is seminal and synthetically challenging. In this work, a series of π-conjugated molecules (8-HB-1,

DMAP-Catalyzed Reaction of Diethyl 1,3-Acetonedicarboxylate with 2-Hydroxybenzylideneindenediones: Facile Synthesis of Fluorenone-Fused Coumarins

The base-catalyzed reaction of diethyl 1,3-acetonedicarboxylate with 2-hydroxybenzylidene indenediones was studied. The reaction provides a facile and expeditious protocol for the synthesis of natural product inspired fluorenone-fused coumarins in good to

Synthesis and characterization of 2-benzylidene-1,3-indandione derivatives as in vitro quantification of amyloid fibrils

Timely detection of amyloid aggregations has a critical role in the treatment of degenerative nervous system disorders such as Alzheimer’s, Parkinson’s disease and systemic amyloidosis. Thioflavin T (ThT) is a dye considered for the detection of amyloids.

Diversity-oriented synthesis of chromenopyrrolidines from azomethine ylides and 2-hydroxybenzylidene indandiones via base-controlled regiodivergent (3+2) cycloaddition

An organobase-directed, regiodivergent 1,3-dipolar cycloaddition of azomethine ylides and 2-hydoxybenzylidene indandiones is reported. The scarcely explored reversal of the nucleophilic site in azomethine ylides has been exploited for their regiodivergent (3+2) cycloaddition, which subsequently resulted in two different cascade processes to generate functionally distinct chromenopyrrolidines in a diversity oriented manner.

Chemo- and Diastereoselective Michael-Michael-Acetalization Cascade for the Synthesis of 1,3-Indandione-Fused Spiro[4.5]decan Scaffolds

A novel, organobase-catalyzed and highly chemoselective Michael-Michael-acetalization cascade is presented for the efficient synthesis of spiro-indandione skeletons. Following this very simple protocol, a broad range of products was obtained in good yield

A Chemical Disruptor of the ClpX Chaperone Complex Attenuates the Virulence of Multidrug-Resistant Staphylococcus aureus

The Staphylococcus aureus ClpXP protease is an important regulator of cell homeostasis and virulence. We utilized a high-throughput screen against the ClpXP complex and identified a specific inhibitor of the ClpX chaperone that disrupts its oligomeric sta

Aqueous extract of Balanites roxburghii fruit: A green dispersant for C-C bond formation

An aqueous biosurfactant solution, a biobased green acidic catalyst for Knoevenagel condensation of 1,3-indanedione with aryl aldehydes and tandem Knoevenagel-Michael reaction of 3-methyl-1-phenylpyrazole with aryl aldehydes, has been reported for the fir

Clean synthesis of 2-arylideneindan-1,3-diones in water

A high-yield synthesis of 2-arylideneindan-1,3-diones in water was achieved by the Knoevenagel condensation of indan-1,3-dione with aromatic aldehydes at ambient temperature avoiding the addition of any catalyst. The procedure is simple, efficient, as wel

Synthesis and antimicrobial study of novel 1-aryl-2-oxo-indano[3,2-d] pyrido/pyrimido[1,2-b]pyrimidines

A series of 2-(arylidene)-indan-1, 3-diones 1 were prepared by Knoevenagel reaction between indane-1,3-dione and the appropriate araldehydes. The α,β-enones 1 have been used as a component of Michael addition with equimolar amounts of 2-aminopyridine/2-am

A study on the reaction of 1,3-indandione with Schiff bases: Synthesis of new 1,3-indandiones with expected psychopharmacological and anticoagulant activity

Condensation of the title compound 1 with aldimines gave the 2-arylidene derivatives 3-9 instead of the expected Mannich bases 2. Compounds 10-11 were obtained from 1 and aldimines of α-ketoaldehydes. Isatin-anil (12) reacts with 1 to give 13. However, th