2530-32-7Relevant articles and documents
Synthesis, characterization, and properties of copolyanhydrides based on 2-octylsuccinic acid and sebacic acid
Hamdan, Yousef M.,Fu, Shitao,Jiang, Xiangmei,Cheng, Yinhua,Huang, Kaixun,Yu, Kaichao
, p. 762 - 767 (2008/12/22)
2-Octylsuccinic acid and its copolyanhydrides with sebacic acid have been synthesized by melt polycondensation, and were characterized by Fourier transform infrared spectroscopy, 1H NMR, gel permeation chromatography, differential scanning calorimetry, and thermal gravimetric analysis. In vitro studies showed that all copolymers are degradable in phosphate buffer at 37°C. The release profiles of the hydrophilic model drug ciprofloxacin hydrochloride follow first-order release kinetics. CSIRO 2008.
Process for the preparation of 3-substituted thiophenes
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, (2008/06/13)
The invention relates to a process for the preparation of 3-substituted thiophenes in which the substituent is a C4 -C18 -alkyl group. According to the invention, the preparation is carried out by allowing an alkali metal salt of a C4 -C18 -alkyl-succinic acid to react with a compound of sulfur and phosphorus, e.g. tetraphosphorus decasulfide, in an organic solvent at a temperature of 100°-180° C., the product obtained being 3-(C4 -C18 -alkyl)thiophene. The said reaction may be the last step in a process in which the initial material is maleic acid anhydride with which α-C4 -C18 -alkene is combined so that C4 -C18 -alkenylsuccinic acid anhydride is obtained, whereafter this is hydrogenated catalytically to produce C4 -C18 -alkylsuccinic acid anhydride. This is thereafter reacted with an alkali metal hydroxide so that an alkali salt of the C4 -C18 -alkylsuccinic acid is obtained, which salt is reacted with a compound of sulfur and phosphorus to produce 3-(C4 -C18 -alkyl)thiophene, which constitutes the final product.