2530-54-3Relevant academic research and scientific papers
Studies on organophosphorus compounds 68. A new and facile synthetic approach to alkylidenebisphosphonates
Li, Chaozhong,Yuan, Chengye
, p. 1515 - 1516 (1993)
Condensation of aldehydes with diethyl phosphite followed by sulfonylation of the α-hydroxy group formed with methanesulfonyl chloride and subsequent substitution by another molecule of diethylphosphite provides corresponding alkylidenebisphosphonates in one-pot procedure with good yield.
Synthesis of new functionalized aryl-substituted methylphosphonic and methylenediphosphonic acids and their derivatives
Prishchenko, Andrey A.,Livantsov, Mikhail V.,Novikova, Olga P.,Livantsova, Ludmila I.,Petrosyan, Valery S.
, p. 381 - 388 (2016/12/14)
The convenient syntheses of new aryl-substituted hydroxymethylphosphonic and methylenediphosphonic acids from the aromatic aldehydes, their derivatives, and phosphorous acid esters in the presence of the effective catalysts (trimethylsilyl trifluoromethanesulfonate, zinc chloride, and cadmium iodide) were developed.
Modified Colorants and Inkjet Ink Compositions Comprising Modified Colorants
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Paragraph 0241-0244, (2016/04/09)
The present invention relates to a modified colorant comprising a colorant having attached at least one organic group. Various embodiments of the organic group are disclosed. For each of these embodiments, preferably the organic group has a defined calciu
Bis-phosphonate compounds
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, (2008/06/13)
The present invention provides a pharmaceutical compound, or pharmaceutically acceptable salt thereof, for use in medicine, wherein said compound is of formula I wherein R is a pharmaceutically active moiety; Ar is an aromatic moiety; X is a linker group; and Y is a moiety comprising two phosphonate groups. Further aspects of the invention relate to a method for palliative and curative treatment of bone disorders and cancer related disorders, such as breast cancer.
Bis-phosphonate compounds
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, (2008/06/13)
The present invention provides a pharmaceutical compound, or pharmaceutically acceptable salt thereof, for use in medicine, wherein said compound is of formula I wherein R is a pharmaceutically active moiety; Ar is an aromatic moiety; X is a linker group; and Y is a moiety comprising two phosphonate groups. Further aspects of the invention relate to a method for palliative and curative treatment of bone disorders and cancer related disorders, such as breast cancer.
ALKYLIDENEDIPHOSPHONATES ET VINYLPHOSPHONATES: UNE DEMARCHE SYNTHETIQUE SELECTIVE PAR VOIE CARBANIONIQUE
Teulade, Marie-Paule,Savignac, Philippe,Aboujaoude, Elie Elia,Lietge, Stephane,Collignon, Noel
, p. 283 - 300 (2007/10/02)
Phosphonoalkylation of acylchloro-phosphates or -phosphinates in the presence of excess lithium diisopropylamide leads to direct generation of lithiated methylenediphosphonate anions.This stable type of anion can be either protonated in acidic medium to provide tetrasubstituted methylenediphosphonate or alkylated.When aliphatic or aromatic aldehydes are added spontaneous formation of vinylphosphonates is observed.This process is a simple and convenient route to diphosphonic as well as to vinylphosphonic compounds.
