Studies on organophosphorus compounds 68. A new and facile synthetic approach to alkylidenebisphosphonates

Article abstract of DOI:10.1016/S0040-4039(00)60333-7

Condensation of aldehydes with diethyl phosphite followed by sulfonylation of the α-hydroxy group formed with methanesulfonyl chloride and subsequent substitution by another molecule of diethylphosphite provides corresponding alkylidenebisphosphonates in one-pot procedure with good yield.