25308-83-2

Upstream product

• 75-87-6 chloral 
• 75-36-5 acetyl chloride 
• 115-11-7 isobutene 
• 25308-82-1 1,1,1-trichloro-4-methyl-4-penten-2-ol 
• 108-24-7 acetic anhydride 

Downstream Products

• 55667-43-1 1,1-dichloro-4-methyl-penta-1,3-diene 

Relevant academic research and scientific papers

Liebeskind-Srogl cross-coupling on γ-carboxyl-γ-butyrolactone derivatives: Application to the side chain of amphidinolides C and F

The synthetic approach for the C20-C29 and C20-C34 fragments of amphidinolide F and C was based on an original Liebeskind-Srogl cross-coupling reaction with a glutamic acid-derived building-block. Further highly diastereoselective reduction of the ketone was achieved by using an uncommon Ph3SiH/TBAF/HMPA system. The amphidinolide C side chain was built through a reductive elimination of chiral epoxide to install the stereogenic center at C29.

Asymmetrical ene reaction of 2-methylpropene with 2,3-dichloropropanal and chloral in the presence of chiral methyloxyaluminum dichloride

The catalytic ene reaction of 2-methylpropene with 2,3-dichloropropanal and chloral was carried out in the presence of l-methyloxyaluminum dichloride, leading to optically active homoallylic chlorohydrins with good enantiomeric purity.

Process for the preparation of unsaturated geminal dihalogen compounds

The invention relates to a new process for preparing unsaturated geminal dihalogen compounds. More particularly, the invention concerns a process for preparing compounds of the formula (I) STR1 wherein X is halogen, R1 is a straight or branched chained alkenyl group having 2 to 6 carbon atoms, by clearing the corresponding 1-substituted 2,2,2-trihaloethylesters.

(2,2-Disubstituted vinyl)γ-butyrolactones

(2,2-Disubstituted vinyl)-γ-butyrolactones of the formula: STR1 in which R1 and R2 are hydrogen or C1 -C6 alkyl, preferably methyl, R3 and R4 are hydrogen, C1 -C6 alkyl, preferably methyl, or halogen, or, together with the carbon atom to which they are attached, form a cycloalkyl group, and R5 is C1 -C6 alkyl, are prepared by condensing an epoxide of the formula: STR2 with a malonic acid ester of the formula: STR3 in a basic medium. The butyrolactones of formula I are valuable intermediates for the synthesis of synthetic pyrethroids having insecticidal activity.

Electrochemical synthesis of insecticide intermediates

1,1,1-Trihalo-4-methylpentenes, carrying 2-substituents selected from those conjugate bases of Bronsted acids which are leaving groups in beta eliminations, are reduced electrochemically to 1,1-dihalo-4-methylpentadienes, intermediates in the synthesis of pyrethroid insecticides.