253143-30-5

Basic information

• Product Name: (R)-4-benzyl-3-((S)-2-ethylpent-4-enoyl)oxazolidin-2-one
• Synonyms: (R)-4-benzyl-3-((S)-2-ethylpent-4-enoyl)oxazolidin-2-one
• CAS NO: 253143-30-5
• Molecular Weight: 287.359
• Mol File: 253143-30-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (R)-4-benzyl-3-((S)-2-ethylpent-4-enoyl)oxazolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-4-benzyl-3-((S)-2-ethylpent-4-enoyl)oxazolidin-2-one(253143-30-5)
• EPA Substance Registry System: (R)-4-benzyl-3-((S)-2-ethylpent-4-enoyl)oxazolidin-2-one(253143-30-5)

Safety Data

• Hazardous Substances Data: 253143-30-5(Hazardous Substances Data)

Upstream product

• 556-56-9 allyl iodid 
• 111292-87-6 (R)-3-(1-butyryl)-4-benzyloxazolidine-2-one 
• 40217-17-2 (R)-4-(phenylmethyl)-2-oxazolidinone 
• 106-95-6 allyl bromide 

Downstream Products

• 253143-39-4 (2S,3S,6S)-2-{(4S,5R,6S)-6-[(1S,3S)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-1-methyl-pentyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-3-hydroxy-6-methyl-dec-9-en-5-one 
• 253143-35-0 {(2S,4S)-4-[(4S,5R,6S)-6-((S)-2-Benzyloxy-1-methyl-ethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-2-ethyl-pentyloxy}-tert-butyl-diphenyl-silane 
• 253143-34-9 (2S,4R,5S,6S,8S)-1-Benzyloxy-8-(tert-butyl-diphenyl-silanyloxymethyl)-5-hydroxy-2,4,6-trimethyl-decan-3-one 
• 253143-36-1 (R)-2-{(4R,5R,6S)-6-[(1S,3S)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-1-methyl-pentyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-propionaldehyde 
• 382138-93-4 (5S,8S,9S,10S,11S,12S,13S,15S)-15-(tert-Butyl-diphenyl-silanyloxymethyl)-8-hydroxy-10-(4-methoxy-benzyloxy)-5,9,11,13-tetramethyl-12-triethylsilanyloxy-1-trimethylsilanyl-heptadec-1-yn-6-one 
• 382139-17-5 2,2-Dimethyl-propionic acid (2S,4S,5S,6S,7S,8S)-8-[(4S,6S)-2,2-dimethyl-6-((S)-1-methyl-pent-4-ynyl)-[1,3]dioxan-4-yl]-2-ethyl-7-(4-methoxy-benzyloxy)-4,6-dimethyl-5-triethylsilanyloxy-nonyl ester 
• 382139-13-1 (2S,3S,4S,5S,6S,8S)-8-(tert-Butyl-diphenyl-silanyloxymethyl)-3-(4-methoxy-benzyloxy)-2,4,6-trimethyl-5-triethylsilanyloxy-decan-1-ol 
• 382138-97-8 (2S,4S,5S,6S,7S,8S)-8-[(4S,6S)-2,2-Dimethyl-6-((S)-1-methyl-pent-4-ynyl)-[1,3]dioxan-4-yl]-2-ethyl-7-(4-methoxy-benzyloxy)-4,6-dimethyl-5-triethylsilanyloxy-nonanoic acid methyl ester 
• 382139-18-6 (2S,4S,5S,6S,7S,8S)-8-[(4S,6S)-2,2-Dimethyl-6-((S)-1-methyl-pent-4-ynyl)-[1,3]dioxan-4-yl]-2-ethyl-7-(4-methoxy-benzyloxy)-4,6-dimethyl-5-triethylsilanyloxy-nonanoic acid amide 
• 382138-90-1 (2S,4S,5S)-4-[(1S,2S,3S,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-1,3-dimethyl-2-triethylsilanyloxy-heptyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxane 
• 382138-96-7 (2S,4S,5S,6S,7S,8S)-8-[(4S,6S)-2,2-Dimethyl-6-((S)-1-methyl-pent-4-ynyl)-[1,3]dioxan-4-yl]-2-ethyl-7-(4-methoxy-benzyloxy)-4,6-dimethyl-5-triethylsilanyloxy-nonan-1-ol 
• 382138-91-2 (2R,3R,4S,5S,6S,8S)-8-(tert-Butyl-diphenyl-silanyloxymethyl)-3-(4-methoxy-benzyloxy)-2,4,6-trimethyl-5-triethylsilanyloxy-decanal 
• 382139-16-4 2,2-Dimethyl-propionic acid (2S,4S,5S,6R,7R,8S)-8-[(4S,6S)-2,2-dimethyl-6-((S)-1-methyl-pent-4-ynyl)-[1,3]dioxan-4-yl]-2-ethyl-5-hydroxy-7-(4-methoxy-benzyloxy)-4,6-dimethyl-nonyl ester 
• 382138-98-9 (2S,4S,5S,6R,7R,8S)-8-[(4S,6S)-2,2-Dimethyl-6-((S)-1-methyl-pent-4-ynyl)-[1,3]dioxan-4-yl]-2-ethyl-5-hydroxy-7-(4-methoxy-benzyloxy)-4,6-dimethyl-nonanoic acid amide 

Relevant articles and documents

Thermal proteome profiling efficiently identifies ribosome destabilizing oxazolidinones

Identifying the targets of bioactive small molecules is a challenging endeavor for which no general solution currently exists. Classical affinity purification experiments suffer from the need to functionalise a bioactive compound and link it to a solid support, which may interfere with target binding. A modern mass spectrometry-based proteomics technique that has partially circumvented this problem is thermal proteome profiling (TPP), which determines the effect of an unmodified small molecule on the thermal stability of the whole proteome simultaneously. Here, we use TPP to identify the mode-of-action of a newly-discovered autophagy inhibitor based on oxazolidinones often employed as chiral auxiliaries. Surprisingly, a significant portion of all ribosomal proteins were found to be destabilized by the inhibitor, highlighting the utility of this technology for determining a challenging mode-of-action.

Synthesis of the tripeptide (C1-N12) and hydroxylated hexadecene (C26-C41) domains of sanglifehrin A and C

Fully enantio-controlled routes to two major segments of the newly discovered immunosuppressants sanglifehrin A and C are described.