253184-99-5

Upstream product

• 253184-98-4 1,11-dibenzyloxy 2R,10S-di-(t-butyldimethylsiloxy)-6-undecanol 
• 58931-16-1 (R)-1-benzyloxypent-4-en-2-ol 
• 98892-19-4 5-benzyloxy 4R-t-butyldimethylsiloxy 1-pentanol 
• 253184-93-9 (-)-(2R)-1-benzyloxy-2-(tert-butyldimethylsilyloxy)pent-4-ene 
• 253184-97-3 5-benzyloxy 4R-t-butyldimethylsiloxy 1-hexanal 
• 253184-95-1 5-benzyloxy 4R-t-butyldimethylsiloxy 1-pentyl bromide 
• 253184-96-2 5-benzyloxy 4R-t-butyldimethylsiloxy 1-pentyl cyanide 
• 253184-94-0 5-benzyloxy 4R-t-butyldimethylsiloxy 1-pentyl mesylate 

Relevant academic research and scientific papers

Synthetic spiroketal pyranes as potent anti-cancer agents

Novel tubulin binding compounds (SPIKETS) having potent tubulin depolymerization activity and inhibitory activity against tubulin polymerization. The compounds are effective agents for inhibiting cellular proliferation, for example, in cancer cells. The compounds are adapted to interact favorably with a novel SP binding pocket on tubulin, which pocket is useful for screening of anti-tubulin, anti-proliferation, and anti-cancer drugs.

Stereocontrolled synthesis of a novel pharmacophore of the tubulin- depolymerizing marine natural product spongistatin

We report here the synthesis and X-ray structure of a novel spiroketal pyran, SPIKET-P1, as a pharmocophore for the tubulin-depolymerizing marine natural product spongistatin 1. Following its retro-synthetic analysis, SPIKET-P1 was prepared using a versatile 11-step synthetic scheme in a stereocontrolled fashion. (C) 2000 Elsevier Science Ltd.