25326-00-5Relevant academic research and scientific papers
Selective synthesis of three product classes from imine and carboxylic acid precursors via direct imine acylation
Rossi-Ashton, James A.,Taylor, Richard J. K.,Unsworth, William P.
supporting information, p. 7527 - 7532 (2017/09/27)
Three divergent Direct Imine Acylation (DIA) procedures are reported that allow the selective generation of δ-lactams, β-lactams and tetrahydropyrimidinones (via a novel three-component coupling) from imine and carboxylic acid precursors. All operate via
β-Lactams from 5,5-difluoroisoxazolidines
Purrington, Suzanne T.,Sheu, Kuen-Wang
, p. 3289 - 3292 (2007/10/02)
1,3-Dipolar cycloaddition of nitrones with 1,1-difluoroolefins gives rise to fluorinated isoxazolidines in 85% yield; subsequent Raney nickel reduction of the cycloadducts produces β-lactams.
