253269-98-6Relevant academic research and scientific papers
Pd-Xantphos-catalyzed direct arylation of nucleosides
Ngassa, Felix N.,DeKorver, Kyle A.,Melistas, Theothora S.,Yen, Edmund A.-H.,Lakshman, Mahesh K.
, p. 4613 - 4616 (2007/10/03)
Direct arylation of the exocyclic amino groups of nucleosides represents a simple approach to N-aryl nucleoside derivatives. To date, one limitation has been that only electron-deficient aryl bromides and triflates possessed adequate reactivity for effici
A general method for the synthesis of the N2- and N6- carcinogenic amine adducts of 2'-deoxyguanosine and 2'-deoxyadenosine
De Riccardis, Francesco,Bonala, Radha R.,Johnson, Francis
, p. 10453 - 10460 (2007/10/03)
A number of simple arylamino compounds (Figure 1) are well-established as pro-carcinogenic agents. Metabolic activation leads to a series of unstable N-hydroxy derivatives that on solvolysis, give nitrenium ions. The latter, which are regarded as the prim
