253274-26-9

Basic information

• Product Name: 1-(3-cyanophenyl)-3-iodoindole-2-carboxylic acid ethyl ester
• Synonyms: 1-(3-cyanophenyl)-3-iodoindole-2-carboxylic acid ethyl ester
• CAS NO: 253274-26-9
• Molecular Weight: 416.218
• Mol File: 253274-26-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(3-cyanophenyl)-3-iodoindole-2-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-cyanophenyl)-3-iodoindole-2-carboxylic acid ethyl ester(253274-26-9)
• EPA Substance Registry System: 1-(3-cyanophenyl)-3-iodoindole-2-carboxylic acid ethyl ester(253274-26-9)

Safety Data

• Hazardous Substances Data: 253274-26-9(Hazardous Substances Data)

Upstream product

• 117637-79-3 ethyl 3-iodo-1H-indole-2-carboxylate 
• 150255-96-2 (3‐cyanophenyl)boronic acid 

Relevant articles and documents

N-aryl heterocycles via coupling reactions with arylboronic acids

Compounds having a partial 2-pyridone structure or 3-pyridazinones can be selectively N-arylated with phenylboronic acids according to the procedure described by Chan and Lam. This procedure leads to N5-arylated imidazo[4,5- c]pyridin-4-ones, precursors of potent factor Xa inhibitors. In addition, the synthesis of N-aryl substituted pyrrole- and indole-2-carboxylic acid esters is described. In the indole series this procedure offers a flexible entry in the synthesis of different 1,3-diaryl-2-carboxyindoles.