253276-99-2Relevant articles and documents
The S-pixyl group: An efficient photocleavable protecting group for the 5' hydroxy function of deoxyribonucleosides
Coleman, Michael P.,Boyd, Mary K.
, p. 7911 - 7915 (2007/10/03)
The 9-phenylthioxanthyl (S-pixyl or S-Px) group has been investigated as a photocleavable protecting group for primary alcohols, and specifically as a 5' hydroxy protecting group for deoxyribonucleosides. Several alcohols, including the four nucleosides with protected exocyclic amino functions, were protected in very good to excellent yield by treatment of 9-chloro-9-phenylthioxanthene 3 in dry pyridine to reveal the derivatized compounds. Irradiation of the protected substrates in neutral, aqueous solution regenerated the starting alcohols in excellent yield.