253305-67-8Relevant academic research and scientific papers
Trideuteromethylation Enabled by a Sulfoxonium Metathesis Reaction
Shen, Zuyuan,Zhang, Shilei,Geng, Huihui,Wang, Jiarui,Zhang, Xinyu,Zhou, Anqi,Yao, Cheng,Chen, Xiaobei,Wang, Wei
supporting information, p. 448 - 452 (2019/01/14)
A conceptually novel sulfoxonium metathesis reaction between TMSOI and cost-effective DMSO-d6 is developed for the efficient generation of a new trideuteromethylation reagent TDMSOI. The new reagent TDMSOI is produced highly efficiently by simply heating a mixture of TMSOI and DMSO-d6 and directly used for subsequent trideuteromethylation in a "one-pot" operation. The preparative power of the new versatile reagent and the "one-pot" protocol is demonstrated by its use to install the ?CD3 moiety into broad functionalities including phenols, thiophenols, acidic amines, and enolizable methylene units in high yield and at a useful level of deuteration (>87% D).
Synthesis of deuterium labelled desulfoglucosinolates as internal standards for LC-MS analysis
Robertson, Avril A. B.,Botting, Nigel P.
, p. 13269 - 13284 (2007/10/03)
The syntheses of three deuterium labelled desulfoglucosinolates are described. These are the phenethyl, 1- methoxyindolyl and 4-methoxyindolyl derivatives. The compounds were prepared as internal standards for use in the quantitative LC-MS analysis of glu
