253305-67-8

Basic information

• Product Name: 1-(methoxy-d₃)-2-methyl-3-nitrobenzene
• Synonyms: 1-(methoxy-d₃)-2-methyl-3-nitrobenzene
• CAS NO: 253305-67-8
• Molecular Weight: 170.141
• Mol File: 253305-67-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(methoxy-d₃)-2-methyl-3-nitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(methoxy-d₃)-2-methyl-3-nitrobenzene(253305-67-8)
• EPA Substance Registry System: 1-(methoxy-d₃)-2-methyl-3-nitrobenzene(253305-67-8)

Safety Data

• Hazardous Substances Data: 253305-67-8(Hazardous Substances Data)

Upstream product

• 5460-31-1 3-nitro-o-cresol 
• 23726-00-3 <²H9>trimethylsulphoxonium iodide 
• 865-50-9 iodomethane-d3 

Relevant articles and documents

Trideuteromethylation Enabled by a Sulfoxonium Metathesis Reaction

A conceptually novel sulfoxonium metathesis reaction between TMSOI and cost-effective DMSO-d6 is developed for the efficient generation of a new trideuteromethylation reagent TDMSOI. The new reagent TDMSOI is produced highly efficiently by simply heating a mixture of TMSOI and DMSO-d6 and directly used for subsequent trideuteromethylation in a "one-pot" operation. The preparative power of the new versatile reagent and the "one-pot" protocol is demonstrated by its use to install the ?CD3 moiety into broad functionalities including phenols, thiophenols, acidic amines, and enolizable methylene units in high yield and at a useful level of deuteration (>87% D).