253327-69-4

Upstream product

• 253327-67-2 (3R,4S)-3-(tert-Butyl-dimethyl-silanyloxy)-4-(3-triethylsilanyloxymethyl-phenyl)-azetidin-2-one 
• 253327-68-3 (3R,4S)-3-(tert-Butyl-dimethyl-silanyloxy)-4-(3-hydroxymethyl-phenyl)-azetidin-2-one 
• 253327-66-1 [1-(3-Triethylsilanyloxymethyl-phenyl)-meth-(E)-ylidene]-trimethylsilanyl-amine 
• 253327-65-0 3-triethylsilanyloxymethyl-benzaldehyde 
• 52010-98-7 3-(hydroxymethyl)benzaldehyde 

Downstream Products

• 253327-70-7 3-[(2S,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-4-oxo-azetidin-2-yl]-benzoic acid benzyl ester 
• 253327-71-8 3-[(2S,3R)-1-Benzoyl-3-(tert-butyl-dimethyl-silanyloxy)-4-oxo-azetidin-2-yl]-benzoic acid benzyl ester 
• 253327-76-3 C₆₀H₇₇NO₁₆Si₂ 
• 253327-75-2 C₆₀H₇₉NO₁₇Si₂ 
• 253327-74-1 C₇₄H₉₁NO₁₇Si₂ 

Relevant academic research and scientific papers

Conformationally restricted paclitaxel analogues: Macrocyclic mimics of the 'hydrophobic collapse' conformation

Conformationally restricted macrocyclic analogues of paclitaxel were prepared, by connecting the 3'-phenyl group the 2-benzoate moiety with two-atom tethers to mimic the 'hydrophobic collapse' paclitaxel conformation. The analogues did not show activity in a tubulin assembly assay.