253327-76-3Relevant articles and documents
Conformationally restricted paclitaxel analogues: Macrocyclic mimics of the 'hydrophobic collapse' conformation
Boge, Thomas C.,Wu, Zhi-Jun,Himes, Richard H.,Vander Velde, David G.,Georg, Gunda I.
, p. 3047 - 3052 (2007/10/03)
Conformationally restricted macrocyclic analogues of paclitaxel were prepared, by connecting the 3'-phenyl group the 2-benzoate moiety with two-atom tethers to mimic the 'hydrophobic collapse' paclitaxel conformation. The analogues did not show activity in a tubulin assembly assay.