253329-18-9

Upstream product

• 26307-50-6 4-bromo-2-isopropyl-phenol 
• 393836-16-3 {4-[(Z)-11-(Butyl-methyl-carbamoyl)-1-(3-isopropyl-4-triisopropylsilanyloxy-phenyl)-undec-4-enyl]-3,5-dimethyl-phenoxy}-acetic acid methyl ester 
• 253329-23-6 {4-[(3-isopropyl-4-triisopropylsilanyloxy-phenyl)-methoxy-methyl]-3,5-dimethyl-phenoxy}-acetic acid methyl ester 
• 253329-13-4 4-[(3-isopropyl-4-triisopropylsilanyloxy-phenyl)-methoxy-methyl]-3,5-dimethyl-phenol 
• 253329-09-8 4-bromo-2-isopropyl-1-triisopropylsilanyloxybenzene 
• 134414-26-9 N-butyl-N-methyl-8-bromooctanamide 
• 7463-51-6 4-bromo-3,5-dimethylphenol 
• 17696-11-6 8-bromooctanoic acid 
• 88-69-7 2-(1-methylethyl)phenol 
• 110-68-9 N-n-butyl-N-methylamine 
• 253329-17-8 {4-[11-(butyl-methyl-carbamoyl)-1-(3-isopropyl-4-triisopropylsilanyloxy-phenyl)-undecyl]-3,5-dimethyl-phenoxy}-acetic acid methyl ester 
• 253329-28-1 5-(tert-Butyl-methoxy-phenyl-silanyloxy)-2-[(3-isopropyl-4-triisopropylsilanyloxy-phenyl)-methoxy-methyl]-1,3-dimethyl-benzene 
• 253329-12-3 [4-(tert-butyl-methoxy-phenyl-silanyloxy)-2,6-dimethyl-phenyl]-(3-isopropyl-4-triisopropylsilanyloxy-phenyl)-methanol 
• 253329-14-5 {4-[4-hydroxy-1-(3-isopropyl-4-triisopropylsilanyloxy-phenyl)-butyl]-3,5-dimethyl-phenoxy}-acetic acid methyl ester 

Relevant academic research and scientific papers

THYROID HORMONE ANALOGUES AND METHODS FOR THEIR PREPARATION

Thyroid hormone analogues are disclosed. Methods of using such analogues and pharmaceutical compositions containing them are also disclosed, as are novel procedures for their preparation.

A designed antagonist of the thyroid hormone receptor.

We synthesized an analogue of the thyromimetic GC-1 bearing the same hydrophobic appendage as the estrogen receptor antagonist ICI-164,384. While having reduced affinity for the thyroid hormone receptors compared to GC-1, it behaves in a manner consistent