25341-88-2Relevant academic research and scientific papers
Chemo- and Stereoselective Cross Rauhut–Currier-Type Reaction of Tri-substituted Alkenes Containing Trifluoromethyl Groups
He, Xiang-Hong,Yang, Lei,Ji, Yan-Ling,Zhao, Qian,Yang, Ming-Cheng,Huang, Wei,Peng, Cheng,Han, Bo
, p. 1947 - 1955 (2018)
A chemoselective cross Rauhut–Currier-type reaction has been developed involving a tri-substituted alkene (trifluoromethyl-containing acrylonitrile derivative) with a di- or tri-substituted alkene to yield tetra-substituted double bonds in RC-type products. This approach can support the synthesis of trifluoromethylated tetra-substituted olefins and synthetically important, structurally complex 3-allylic-type oxindole skeletons. The asymmetric version of this RC-type reaction can be realized by combining a Br?nsted acid and Lewis base for bifunctional H-bonding-tertiary amine catalysis. Subsequent transformation of multi-functionalized RC-type product leads to pharmacologically interesting cyclohexane-based spiro-pyrazolones bearing six contiguous chiral centers and two highly congested, vicinal quaternary carbon centers.
