253426-24-3

Basic information

• Product Name: AVE8062A
• Synonyms: AVE8062A;AC 7700;Ombrabulin (hydrochloride);Ombrabulin (AVE8062) HCl
• CAS NO: 253426-24-3
• Molecular Formula: C₂₁H₂₆N₂O₆*ClH
• Molecular Weight: 438.90188
• EINECS: -0
• Mol File: 253426-24-3.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: AVE8062A(CAS DataBase Reference)
• NIST Chemistry Reference: AVE8062A(253426-24-3)
• EPA Substance Registry System: AVE8062A(253426-24-3)

Safety Data

• RTECS: TX1404540
• Hazardous Substances Data: 253426-24-3(Hazardous Substances Data)

Usage

General Description

Ombrabulin is a member of the combretastatin A-4 compound class and is a tubulin-depolymerising tumour vascular-disrupting compound.

Biochem/physiol Actions

Ombrabulin is a synthetic water-soluble combretastatin analog vascular disrupting agent. Ombrabulin is a tubulin polymerization inhibitor. Ombrabulin binds to the colchicine binding site of endothelial cell tubulin, inhibiting tubulin polymerization and inducing mitotic arrest and apoptosis in endothelial cells.

Upstream product

• 181816-48-8 (S,Z)-2-amino-3-hydroxy-N-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)propanamide 
• 61240-20-8 triphenyl-(3,4,5-trimethoxybenzyl)phosphonium bromide 
• 162705-07-9 3-amino-deoxycombretastatin A₄ 
• 162705-13-7 (Z)-1-(4''-methoxy-3''-nitrophenyl)-2-(3',4',5'-trimethoxyphenyl)ethene 
• 286463-65-8 (S,Z)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-((2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)amino)-3-oxopropyl acetate 
• 3840-31-1 (3,4,5-trimethoxyphenyl)methanol 
• 21852-50-6 3,4,5-trimethoxybenzyl bromide 
• 31680-08-7 4-methoxy-3-nitrobenzaldehyde 

Relevant articles and documents

Compositions and Methods for Treatment of Cancer

Resistance of randomly dispersed and oxygen-starved lung tumor cells to chemo- and radiotherapy constitutes the vast majority recurrences and death from lung cancer. We use sickle cells derived from humans with sickle cell anemia to target oxygen-deprived

COMBRETASTATIN DERIVATIVE PREPARATION METHOD

The invention relates to a method for preparing a combretastatin derivative (I) or (II), said method including the following steps: triaryl(3,4,5-trimethoxybenzyl)phosphonium halide P3 (III), wherein Ar denotes an aryl group selected from among phenyl or thienyl, is reacted with P2 having formula (IV) or P′2 having formula (V) so as to respectively obtain the compound P4 or P′4, which have formulas (VI) and (VII), respectively; then, during a step for deprotection in the presence of an acid and/or a base, the compound having P4 or P′4 leads, after an optional purification step, to the compound having formula (I) or (II).