25343-32-2

Usage

Uses

Used in Pharmaceutical Industry:
1-(2-Isopropylphenyl)-2-thiourea is used as a reagent in the production of pharmaceuticals for its ability to contribute to the synthesis of various medicinal compounds.
Used in Agrochemical Industry:
1-(2-ISOPROPYLPHENYL)-2-THIOUREA is utilized as a reagent in the production of agrochemicals, playing a role in the development of substances that aid in crop protection and enhancement of agricultural yields.
Used in Dye Industry:
1-(2-Isopropylphenyl)-2-thiourea is employed in the dye industry as a reagent, contributing to the creation of a range of dyes used in various applications.
Used in Rubber Industry:
As a rubber accelerator, 1-(2-Isopropylphenyl)-2-thiourea is used in the production of tires, where it helps to improve the vulcanization process and the overall quality of the rubber products.
Used in Cancer Research:
1-(2-Isopropylphenyl)-2-thiourea is being studied for its potential anti-cancer properties, with research focusing on its ability to inhibit the growth of cancer cells, offering a new avenue for therapeutic intervention in oncology.

InChI:InChI=1/C10H14N2S/c1-7(2)8-5-3-4-6-9(8)12-10(11)13/h3-7H,1-2H3,(H3,11,12,13)

Upstream product

• 25343-23-1 N-((2-isopropylphenyl)carbamothioyl)benzamide 
• 36176-31-5 1-isopropyl-2-isothiocyanatobenzene 
• 102439-84-9 2-isopropyl-aniline; hydrochloride 
• 643-28-7 2-isopropylaniline 

Downstream Products

• 88884-43-9 1-(2-Isopropyl-phenyl)-2-methyl-isothiourea; hydriodide 
• 1417885-18-7 N-[[(2-isopropylphenyl)amino]thioxomethyl]N'-((4-(5-(4-(perfluoroethoxy)phenyl)-1,3,4-oxadiazol-2-yl)phenyl))urea 
• 1417885-36-9 N-[[(2-isopropylphenyl)amino]thioxomethyl]-N'-((4-(1-(4-(trifluoromethoxy)phenyl)-1H-pyrazol-3-yl)phenyl))urea 
• 1417885-44-9 N-[[(2-isopropylphenyl)amino]thioxomethyl]N'-(2-methyl(4-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-3-yl)phenyl))urea 
• 88884-54-2 N-(2-Isopropyl-phenyl)-morpholine-4-carboxamidine; hydriodide 
• 88884-53-1 N-(2-Isopropyl-phenyl)-pyrrolidine-1-carboxamidine; hydriodide 

Relevant academic research and scientific papers

Search for the Active Ingredients from a 2-Aminothiazole DMSO Stock Solution with Antimalarial Activity

Chemical decomposition of DMSO stock solutions is a common incident that can mislead biological screening campaigns. Here, we share our case study of 2-aminothiazole 1, originating from an antimalarial class that undergoes chemical decomposition in DMSO at room temperature. As previously measured biological activities observed against Plasmodium falciparum NF54 and for the target enzyme PfIspE were not reproducible for a fresh batch, we tackled the challenge to understand where the activity originated from. Solvent- and temperature-dependent studies using HRMS and NMR spectroscopy to monitor the decomposition led to the isolation and in vitro evaluation of several fractions against PfIspE. After four days of decomposition, we successfully isolated the oxygenated and dimerised compounds using SFC purification and correlated the observed activities to them. Due to the unstable nature of the two isolates, it is likely that they undergo further decomposition contributing to the overall instability of the compound.

Optimization of 2-aminothiazole derivatives as CCR4 antagonists

A series of 2-aminothiazole-derived antagonists of the CCR4 receptor has been synthesized and their affinity for the receptor evaluated using a [125I]TARC (CCL17) displacement assay. Optimization of these compounds for potency and pharmacokinetic properties led to the discovery of potent, orally bioavailable antagonists.

Synthesis of thiophene-2-carboxamidines containing 2-aminothiazoles and their biological evaluation as urokinase inhibitors

The serine protease urokinase (uPa) has been implicated in the progression of both breast and prostate cancer. Utilizing structure based design, the synthesis of a series of substituted 4-[2-amino-1,3-thiazolyl]-thiophene-2-carboxamidines is described. Further optimization of this series by substitution of the terminal amine yielded urokinase inhibitors with excellent activities.

Substituted N-phenylisothioureas: Potent inhibitors of human nitric oxide synthase with neuronal isoform selectivity

S-Ethyl N-phenylisothiourea (4) has been found to be a potent inhibitor of both the human constitutive and inducible isoforms of nitric oxide synthase. A series of substituted N-phenylisothiourea analogues was synthesized to investigate the structure-activity relationship of this class of inhibitor. Each analogue was evaluated for human isoform selectivity. One analogue, S-ethyl N-[4-(trifluoromethyl)phenyl]isothiourea (39), exhibited 115-fold and 29-fold selectivity for the neuronal isoform versus the inducible and endothelial derived constitutive isoforms, respectively. Studies have shown the substituted N-phenylisothiourea 39 binds competitively with L,-arginine.

Improved Procedures for the Preparation of Cycloalkyl-, Arylalkyl-, and Arylthioureas

An improved procedure for the preparation of arylthioureas consists of the reaction of benzoyl isothiocyanate with anilines in acetone and debenzoylation of the resultant N-aryl-N'-benzoylthioureas with 5percent aqueous sodium hydroxide.Bicycloalkylthioureas and N-(arylalkyl)thioureas (e.g. 9H-9-fluorenylthiourea) are directly prepared from the corresponding isothiocyanates and ammonia.

Heterocyclic derivatives of guanidine

5-Membered, 6-membered and 7-membered heterocyclic derivatives of guanidine having hypoglycemic activity.