253435-14-2Relevant academic research and scientific papers
Synthesis of tetracyclic chromenones via platinum(ii) chloride catalysed cascade cyclization of enediyne-enones
Sivaraman, Mahalingam,Perumal, Paramasivan T.
, p. 1318 - 1327 (2014/03/21)
PtCl2 catalysed cascade cyclization of an enediyne-enone system to afford a tetracyclic chromenone is reported, which proceeds through two consecutive highly regioselective 6-endo-dig cyclizations in a single step with the formation of two new C-C bonds and two new rings in excellent yield. A mechanism for this transformation is proposed based on the isolated intermediates.
Soft propargylic deprotonation: Designed ligand enables au-catalyzed isomerization of alkynes to 1,3-Dienes
Wang, Zhixun,Wang, Yanzhao,Zhang, Liming
supporting information, p. 8887 - 8890 (2014/07/08)
By functionalizing the privileged biphenyl-2-ylphosphine with a basic amino group at the rarely explored 3′ position, the derived gold(I) complex possesses orthogonally positioned "push" and "pull" forces, which enable for the first time soft propargylic deprotonation and permit the bridging of a difference of >26 pKa units (in DMSO) between a propargylic hydrogen and a protonated tertiary aniline. The application of this design led to efficient isomerization of alkynes into versatile 1,3-dienes with synthetically useful scope under mild reaction conditions.
Catalytic generation of arynes and trapping by nucleophilic addition and iodination
Hamura, Toshiyuki,Chuda, Yu,Nakatsuji, Yuya,Suzuki, Keisuke
supporting information; experimental part, p. 3368 - 3372 (2012/06/18)
A fair exchange: In the title reaction, alkynyllithium serves as an initiator for benzyne generation through an iodine-lithium exchange (see scheme; Tf=trifluoromethanesulfonyl). When performed in the presence of stoichiometric amounts of a nucleophile, the generated benzyne undergoes attack by lithio nucleophiles to generate aryllithium, which is then iodinated by iodoalkyne to give the iodoarenes 1. Copyright
Trans- and cis-selective Lewis acid catalyzed hydrogermylation of alkynes
Schwier, Todd,Gevorgyan, Vladimir
, p. 5191 - 5194 (2007/10/03)
(Chemical Equation Presented) The first examples of Lewis acid catalyzed hydrogermylation of alkynes have been demonstrated. It was found that this method has much higher functional group compatibility compared to the known Lewis acid catalyzed hydrosilyl
A direct anionic cyclization of 2-alkynylbenzonitrile to 3- substituted-1(2H)-isoquinolones and 3-benzylideneisoindol-2ones initiated by methoxide addition
Wu, Ming-Jung,Chang, Li-Juan,Wei, Li-Mei,Lin, Chi-Fong
, p. 13193 - 13200 (2007/10/03)
Treatment of 2-(2-alkylethynyl)benzonitrile with sodium methoxide in refluxing methanol for 12 h gave 3-alkyl-1(2H)- isoquinolone in modest yield. Under the same reaction conditions, methanolysis of 2-(2-arylethynyl)benzonitrile lead to the formation of 3
