253440-88-9

Usage

Uses

Used in Pharmaceutical Industry:
2-Pyridinecarboxylic acid, 3,6-dichloro-, ethyl ester is used as a precursor in the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
2-Pyridinecarboxylic acid, 3,6-dichloro-, ethyl ester is used as a key building block in the production of herbicides, playing a crucial role in the development of effective weed control agents.
Used in Environmentally Friendly Herbicides:
2-Pyridinecarboxylic acid, 3,6-dichloro-, ethyl ester has been studied for its potential use as a biodegradable herbicide, offering an eco-friendly alternative to traditional herbicides and reducing the environmental impact of weed control.

Upstream product

• 64-17-5 ethanol 
• 1702-17-6 Clopyralid 
• 6515-09-9 2,3,6-trichloropyridine 
• 201230-82-2 carbon monoxide 

Downstream Products

• 16866-52-7 3,6-dichloropicolinohydrazide 
• 1436504-94-7 ethyl 3-chloro-6-cyanopicolinate 
• 1214363-19-5 ethyl 3,6-difluoropicolinate 
• 1610791-83-7 ethyl 3-fluoro-6-phenylpicolinate 
• 1610791-89-3 ethyl 3-chloro-6-phenylpicolinate 
• 1436504-98-1 ethyl 6-(((tert-butoxycarbonyl)amino)methyl)-3-chloropicolinate 
• 1436504-90-3 ethyl 3-chloro-6-iodopicolinate 

Relevant academic research and scientific papers

INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND/OR TRYPTOPHAN 2,3-DIOXYGENASE

The present invention relates to compounds of Formula (I) inhibiting indoleamine 2,3-dioxygenase (IDO) and/or tryptophan 2,3-dioxygenase (TDO) enzymes. Further, their synthesis and their use as medicaments in the treatment of inter alia cancer is disclose

NOVEL 5 or 8-SUBSTITUTED IMIDAZO [1, 5-a] PYRIDINES AS SELECTIVE INHIBITORS OF INDOLEAMINE AND/OR TRYPTOPHANE 2, 3-DIOXYGENASES

Disclosed herein are 5 or 8-substituted imidazo [1, 5-a] pyridines and pharmaceutical compositions comprising at least one such 5 or 8-substituted imidazo [1, 5-a] pyridines, processes for the preparation thereof, and the use thereof in therapy. Disclosed herein are certain 5 or 8-substituted imidazo [1, 5-a] pyridines that can be useful for inhibiting indoleamine 2, 3-dioxygenase and/or tryptophane 2, 3-dioxygenase and for treating diseases or disorders mediated thereby.

CONDENSED HETEROCYCLIC COMPOUND HAVING CYCLOALKYLPYRIDYL GROUP OR SALTS THEREOF, INSECTICIDE FOR AGRICULTURE AND HORTICULTURE CONTAINING THE COMPOUND, AND METHOD FOR USING THE INSECTICIDE

PROBLEM TO BE SOLVED: To provide a new insecticide for agriculture and horticulture, in consideration of factors such as the occurrence of vermin resistant to existing insecticides, as the damage caused by vermin etc. is still serious in crop production such as agriculture and horticulture. SOLUTION: This invention provides: a condensed heterocyclic compound that has a cycloalkylpyridyl group expressed by formula (1), or salts thereof; an insecticide for agriculture and horticulture containing the compound; and a method for using the insecticide. {R1 is a haloalkyl group; A1 is O or an N-methyl group; A2 and A3 are a CH group or N; Ra, Rb, and Rc are H; m is an integer of 0-2; and n is 1 or 2}. SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT

NOVEL 5 OR 8-SUBSTITUTED IMIDAZO [1, 5-a] PYRIDINES AS INDOLEAMINE AND/OR TRYPTOPHANE 2, 3-DIOXYGENASES

Disclosed herein are 5 or 8-substituted imidazo[l,5-a]pyridines and pharmaceutical compositions comprising at least one such 5 or 8-substituted imidazo[l,5-a]pyridines, processes for the preparation thereof, and the use thereof in therapy. Disclosed herein are certain 5 or 8- substituted imidazo[l,5-a]pyridines that can be useful for inhibiting indoleamine 2,3- dioxygenase and/or tryptophane 2,3-dioxygenase and for treating diseases or disorders mediated thereby.

Mild fluorination of chloropyridines with in situ generated anhydrous tetrabutylammonium fluoride

This paper describes the fluorination of nitrogen heterocycles using anhydrous NBu4F. Quinoline derivatives as well as a number of 3- and 5-substituted pyridines undergo high-yielding fluorination at room temperature using this reagent. These results with anhydrous NBu4F compare favorably to traditional halex fluorinations using alkali metal fluorides, which generally require temperatures of ≥100 °C.

Developing efficient nucleophilic fluorination methods and application to substituted picolinate esters

This report describes nucleophilic fluorination of 3 and 5-substituted picolinate ester substrates using potassium fluoride in combination with additive promoters. Agents such as tributylmethylammonium or tetraphenylphosphonium chloride were among the bes

Synthesis and bioactivities of clopyralid hydrazide-hydrazones

A series of clopyralid hydrazide-hydrazone derivatives (4a-p) have been synthesized. Their structures were confirmed by elemental analysis, infrared, and 1H NMR spectra. The bioactivities of compounds 4a-p were tested with barnyard grass, rape, and S. aureus, but the results showed that they could not be considered the promising herbicidal or antibacterial agents.

The preparation of pyridinecarboxylates from chloropyridines by the palladium-catalyzed alkoxycarbonylation

The preparation of pyridinecarboxylates and pyridinedicarboxylates by alkoxycarbonylation of chloropyridines with carbon monoxide in the presence of palladium acetate and 1,1'-bis(diphenylphosphino)ferrocene is described. The process uses readily available starting materials and affords pyridinecarboxylates in good to very good yields.