253450-80-5

Upstream product

• 556-56-9 allyl iodid 
• 253450-82-7 (4S)-4-benzyl-3-[2-((1R,2R)-2-benzyloxy-1-ethyl-pent-4-enyloxy)-acetyl]-oxazolidin-2-one 
• 253450-86-1 (4S)-4-benzyl-3-[(2R)-2-benzyloxy-pent-4-enoyl]-oxazolidin-2-one 
• 69831-70-5 (2R)-2-benzyloxy-pent-4-en-1-ol 
• 253450-88-3 [(1R,2R)-2-benzyloxy-1-ethyl-pent-4-enyloxy]-acetic acid 
• 236110-81-9 (4S)-4-benzyl-3-[2-(benzyloxy)acetyl]-1,3-oxazolan-2-one 
• 159622-96-5 (R)-(+)-2-Benzyloxypent-4-enal 
• 88223-83-0 (3R,4R)-4-benzyloxy-hept-6-en-3-ol 

Downstream Products

• 3442-58-8 (+)-laurencin 

Relevant academic research and scientific papers

Diastereoselective alkylations of oxazolidinone glycolates: A useful extension of the Evans asymmetric alkylation

matrix presented The diastereoselective alkylation of glycolate oxazolidinones has been demonstrated as a method for the enantioselective preparation of α-alkoxy carboxylic acid derivatives and selectively protected 1,2-diols. Various protecting groups on

Total synthesis of (+)-laurencin: an asymmetric alkylation-ring-closing metathesis approach to medium ring ethers.

[formula: see text] The enantioselective total synthesis of (+)-laurencin 1 is achieved in 18 steps from (S)-(+)-4-benzyl-3-benzyloxyacetyl-2-oxazolidinone. The key steps in this synthesis are an asymmetric glycolate alkylation leading to acyl oxazolidinone 2 and a subsequent ring-closing olefin metathesis to construct the oxocene core of 1. The approach to medium ring ethers utilized in this synthesis provides a general and efficient route to the cyclic core of other marine natural products.