2535-59-3

Usage

Derivative of pyrazole

Heterocyclic compound with a five-membered ring of three carbon atoms and two nitrogen atoms

Substituents

4-methoxyphenyl and phenyl groups attached to the pyrazole ring

Usage

Organic synthesis and medicinal chemistry as a building block for the synthesis of various pharmaceutical and biologically active compounds

Physical and chemical properties

Potentially influenced by the presence of 4-methoxyphenyl and phenyl groups, making it suitable for specific applications

Upstream product

• 4173-65-3 3-[(4-methoxyphenyl)amino]-1-phenylpropan-1-one 
• 21918-04-7 3-(N-(4-methoxyphenyl)-N-nitrosoamino)-1-phenylpropane-1-one 
• 879-72-1 3-(dimethylamino)propiophenone hydrochloride 
• 104-94-9 4-methoxy-aniline 

Relevant academic research and scientific papers

Utility of Ketonic Mannich Bases in Synthesis of Some New Functionalized 2-Pyrazolines

The styryl ketonic Mannich base 2 has been used as a precursor in the synthesis of 2-pyrazolines having a basic side chain at C-3 and a phenolic Mannich base at C-5. Treatment of the bis(styryl ketonic bases) 6a and 8a with phenylhydrazine affords the bis(3-functionalized 2-pyrazolines) 7 and 9. The transamination between the styryl keto base 10 and 4-aminoantipyrine leads to 12, which reacts with piperazine to give 13. N-Nitrosation of the sec-Mannich bases 15a–d followed by reductive cyclization affords 2-pyrazolines 17a–d. The keto base 14b has been used for the synthesis of 2-pyrazolines having a phenolic Mannich base at C-3 and its reaction with 3,5-dimethyl-1H-pyrazole affords 23. The alkylation of 3-methyl-1-phenyl-2-pyrazolin-5-one with the bis(Mannich base) 25 was investigated.