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3-(4-methoxyphenyl)-1-methyl-1-nitrosourea, also known as temozolomide, is a chemotherapeutic agent used in the treatment of various types of cancer, particularly glioblastoma multiforme and anaplastic astrocytoma. It is a second-generation nitrosourea compound that works by forming DNA adducts, leading to DNA damage and ultimately cell death. The drug is administered orally and is rapidly absorbed, with its active metabolite, the methyltriazen-1-yl methylimidazol-4-carboxamide, being responsible for its cytotoxic effects. Temozolomide is considered a standard treatment option for certain brain tumors and is often used in combination with radiation therapy. Its mechanism of action involves the alkylation of DNA, which disrupts the cell's ability to replicate and leads to apoptosis. The drug's effectiveness is influenced by factors such as the patient's age, the tumor's genetic profile, and the presence of certain enzyme levels in the body.

25355-59-3

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25355-59-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 25355-59-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,5,3,5 and 5 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 25355-59:
(7*2)+(6*5)+(5*3)+(4*5)+(3*5)+(2*5)+(1*9)=113
113 % 10 = 3
So 25355-59-3 is a valid CAS Registry Number.

25355-59-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-(4-methoxyphenyl)-1-methyl-1-nitrosourea

1.2 Other means of identification

Product number -
Other names N'-(4-methoxyphenyl)-N-methyl-N-nitroso-urea

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:25355-59-3 SDS

25355-59-3Downstream Products

25355-59-3Relevant academic research and scientific papers

PREPARATION AND PROPERTIES OF 3-ALKYL-i-ARYLNITROSOUREAS AND RELATED COMPOUNDS

Tanno, Masayuki,Sueyoshi, Shoko

, p. 1360 - 1371 (2007/10/02)

Nitrosation of 3-alkyl-1-arylureas was investigated with sodium nitrite in 99percent formic acid or with isoamyl nitrite in chloroform.The preparation of 3-alkyl-1-aryl-1-nitrosoureas was effectively performed by using isoamyl nitrite in the absence of acids, since the 1-nitrosoureas were isomerized to the 3-nitroso isomers by acids.The carbon-13 nuclear magnetic resonance and infrared spectral properties of the products were examined and their structural features are discussed.It was found that 3-alkyl-1-aryl-1-nitrosoureas decomposed to form alkyl isocyanates and 3-alkyl-1-(2-nitroaryl)ureas in carbon tetrachloride. 1,3-Rearrangement and transnitrosation also took place in this solvent.Keywords - 3-alkyl-1-arylnitrosourea; 3,3-diethyl-1-tolyl-1-nitrosourea; N-nitrosourea; nitrosation; 1,3-rearrangement; isomerization; transnitrosation; nitration

Kinetics and Mechanism of Decomposition of N-Methyl-N'-aryl-N-nitrosoureas and Related Compounds in Aqueous Buffer Solution

Yoshida, Kitaro,Yano, Kazuyuki

, p. 2200 - 2203 (2007/10/02)

The decomposition reactions of N-methyl-N'-aryl-N-nitrosoureas (1) and of N,N'-dimethyl-N'-aryl-N-nitrosoureas (2) were studied kinetically in phosphate buffer solution.All nitrosoureas 1 were easily hydrolyzed even under conditions and the rates of hydrolysis were found to be proportional to the hydroxide ion concentration over pH range 5.4-7.6.General base catalysis by buffer components was negligible. The reaction was subjected to the elimination mechanism in which an abstraction of the urcido proton was involved as an initial step.On the other hand, nitrosoureas 2 had no significant reactivity under the same conditions.

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