25364-40-3

Basic information

• Product Name: 1-[2-(1-methylethyl)phenyl]-1H-imidazole
• Synonyms: 1-(2-(1-Methylethyl)phenyl)-1H-imidazole; 1-[2-(propan-2-yl)phenyl]-1H-imidazole; 1H-Imidazole, 1-(2-(1-methylethyl)phenyl)-; 1H-imidazole, 1-[2-(1-methylethyl)phenyl]-
• CAS NO: 25364-40-3
• Molecular Formula: C₁₂H₁₄N₂
• Molecular Weight: 186.253
• Mol File: 25364-40-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 312.2°C at 760 mmHg
• Flash Point: 142.6°C
• Density: 1.02g/cm³
• Vapor Pressure: 0.000986mmHg at 25°C
• Refractive Index: 1.564
• CAS DataBase Reference: 1-[2-(1-methylethyl)phenyl]-1H-imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[2-(1-methylethyl)phenyl]-1H-imidazole(25364-40-3)
• EPA Substance Registry System: 1-[2-(1-methylethyl)phenyl]-1H-imidazole(25364-40-3)

Safety Data

• Hazardous Substances Data: 25364-40-3(Hazardous Substances Data)

Usage

Type of Compound

Antifungal medication

Purpose

Treats fungal infections such as athlete's foot, jock itch, and ringworm

Mechanism of Action

Disrupts the cell membrane of fungi, leading to their death

Available Forms

Creams, powders, and solutions

Application Method

Topically applied directly to the affected area

Safety

Generally considered safe for topical use

Upstream product

• 50-00-0 formaldehyd 
• 131543-46-9 Glyoxal 
• 643-28-7 2-isopropylaniline 
• 288-32-4 1H-imidazole 
• 19099-54-8 2-isopropyliodobenzene 

Relevant articles and documents

Nickel-Catalyzed Deoxygenative Deuteration of Aryl Sulfamates

The nickel-catalyzed deoxygenative deuteration of aryl/heteroaryl sulfamates has been developed, and the effective incorporation of deuterium into a variety of aromatic compounds was achieved with sufficient catalytic efficiency and high deuteration degree. This process tolerated reducible functional moieties and heterocyclic structures. Additionally, a double introduction of deuterium also successfully gave a desired product with a high yield and deuterium content. (Figure presented.).

Copper-catalyzed N-arylation of imidazoles and benzimidazoles

(Chemical Equation Presented) 4,7-Dimethoxy-1,10-phenanthroline (L1c) was found to be an efficient ligand for the copper-catalyzed N-arylation of imidazoles and benzimidazoles with both aryl iodides and bromides under mild conditions. Further optimization of the system has revealed that the addition of poly(ethylene glycol) accelerates this reaction. A variety of hindered and functionalized imidazoles, benzimidazoles, and aryl halides were transformed in good to excellent yields. Heteroaryl halides were also coupled in moderate to good yields. We also present the results obtained from a series of coupling reactions, which directly compare the use of L1c with other recently reported ligands.