25364-40-3Relevant academic research and scientific papers
Nickel-Catalyzed Deoxygenative Deuteration of Aryl Sulfamates
Kuriyama, Masami,Kujirada, Shota,Tsukuda, Kotaro,Onomura, Osamu
, p. 1043 - 1048 (2017/03/27)
The nickel-catalyzed deoxygenative deuteration of aryl/heteroaryl sulfamates has been developed, and the effective incorporation of deuterium into a variety of aromatic compounds was achieved with sufficient catalytic efficiency and high deuteration degree. This process tolerated reducible functional moieties and heterocyclic structures. Additionally, a double introduction of deuterium also successfully gave a desired product with a high yield and deuterium content. (Figure presented.).
Palladium-catalyzed β-arylation of silyl ketene acetals and application to the synthesis of benzo-fused δ-lactones
Aspin, Sam,Lopez-Suarez, Laura,Larini, Paolo,Goutierre, Anne-Sophie,Jazzar, Rodolphe,Baudoin, Olivier
supporting information, p. 5056 - 5059 (2013/10/22)
Silyl ketene acetals are shown to be competent nucleophiles in Pd-catalyzed migrative C(sp3)-H arylations. Compared to the parent ester lithium enolates, they possess decreased reactivity but enhanced chemoselectivity. This behavior was exploited through the synthesis of valuable benzo-fused δ-lactones such as 1-isochromanones and dihydrocoumarins.
Copper-catalyzed N-arylation of imidazoles and benzimidazoles
Altman, Ryan A.,Koval, Erica D.,Buchwald, Stephen L.
, p. 6190 - 6199 (2008/02/10)
(Chemical Equation Presented) 4,7-Dimethoxy-1,10-phenanthroline (L1c) was found to be an efficient ligand for the copper-catalyzed N-arylation of imidazoles and benzimidazoles with both aryl iodides and bromides under mild conditions. Further optimization of the system has revealed that the addition of poly(ethylene glycol) accelerates this reaction. A variety of hindered and functionalized imidazoles, benzimidazoles, and aryl halides were transformed in good to excellent yields. Heteroaryl halides were also coupled in moderate to good yields. We also present the results obtained from a series of coupling reactions, which directly compare the use of L1c with other recently reported ligands.
4,7-Dimethoxy-1,10-phenanthroline: An excellent ligand for the Cu-catalyzed N-arylation of imidazoles
Altman, Ryan A.,Buchwald, Stephen L.
, p. 2779 - 2782 (2007/10/03)
4,7-Dimethoxy-1,10-phenanthroline (L) was found to be an efficient ligand for the copper-catalyzed N-arylation of imidazole with aryl iodides and bromides under mild conditions. A variety of hindered and functionalized imidazoles and aryl halides were transformed in good to excellent yields.
