19099-54-8

Basic information

• Product Name: 2-IODOISOPROPYLBENZENE
• Synonyms: 2-IODOISOPROPYLBENZENE;2-IODOCUMENE;1-IODO-2-ISOPROPYLBENZENE;2-Iodocumene~2-Isopropyliodobenzene;Iodocumene;o-iodocumene;2-isopropyliodobenzene;1-IODO-2-ISOPROPYL BENZENE 95%
• CAS NO: 19099-54-8
• Molecular Formula: C₉H₁₁I
• Molecular Weight: 246.09
• EINECS: 242-819-8
• Mol File: 19099-54-8.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 89 °C
• Flash Point: 110°C/20mm
• Appearance: /
• Density: 1.54
• Vapor Pressure: 0.0981mmHg at 25°C
• Refractive Index: 1.5801
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• Sensitive: Light Sensitive
• BRN: 2351872
• CAS DataBase Reference: 2-IODOISOPROPYLBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-IODOISOPROPYLBENZENE(19099-54-8)
• EPA Substance Registry System: 2-IODOISOPROPYLBENZENE(19099-54-8)

Safety Data

• Hazard Codes: Xi,N
• Statements: 36/37/38-50/53-41-37/38
• Safety Statements: 26-36/37/39-61-60-39
• Hazardous Substances Data: 19099-54-8(Hazardous Substances Data)

Usage

Uses

2-Iodocumene acts as a reagent in the synthesis of aryliminoguanidines as NPFF1 and NPFF2 agonists.

InChI:InChI=1/C9H11I/c1-7(2)8-5-3-4-6-9(8)10/h3-7H,1-2H3

Upstream product

• 7073-94-1 1-bromo-2-isopropylbenzene 
• 1062267-52-0 2-(propan-2-yl)phenyl 4-methylbenzenesulfonate 
• 591-50-4 iodobenzene 
• 1474011-51-2 (4,4'-(di-tert-butyl)-2,2'-bipyridine)Ni^II(2-isopropylphenyl)(I) 
• 7553-56-2 iodine 
• 98-82-8 Isopropylbenzene 
• 643-28-7 2-isopropylaniline 

Downstream Products

• 105436-18-8 1-isopropyl-2-(1,2,2-trifluorovinyl)benzene 
• 104846-93-7 (Z)-3-(2-Isopropyl-phenyl)-acrylic acid methyl ester 
• 1147014-57-0 [(2-isopropylphenyl)ethynyl]trimethylsilane 
• 31539-92-1 2-iodo-5-nitroisopropylbenzene 
• 1147014-97-8 4-bromo-1-iodo-2-isopropylbenzene 
• 1147014-43-4 4-((2-isopropylphenyl)ethynyl)-7H-pyrrolo[2,3-d]pyrimidine 
• 1147014-55-8 2-chloro-4-((2-isopropylphenyl)ethynyl)-7H-pyrrolo[2,3-d]pyrimidine 
• 1160758-46-2 trans-bis(triphenylphosphino)(2-isopropylphenyl)palladium(II) iodide 
• 1188273-04-2 3,2'-di-i-propyl-2-(2-oxo-2-phenylethyl)-1,1'-biphenyl 
• 1188273-08-6 3,2'-di-i-propyl-2-(1-methyl-2-oxo-2-phenylethyl)-1,1'-biphenyl 
• 98-82-8 Isopropylbenzene 

Relevant articles and documents

Generation of Organozinc Reagents by Nickel Diazadiene Complex Catalyzed Zinc Insertion into Aryl Sulfonates

The generation of arylzinc reagents (ArZnX) by direct insertion of zinc into the C?X bond of ArX electrophiles has typically been restricted to iodides and bromides. The insertions of zinc dust into the C?O bonds of various aryl sulfonates (tosylates, mesylates, triflates, sulfamates), or into the C?X bonds of other moderate electrophiles (X=Cl, SMe) are catalyzed by a simple NiCl2–1,4-diazadiene catalyst system, in which 1,4-diazadiene (DAD) stands for diacetyl diimines, phenanthroline, bipyridine and related ligands. Catalytic zincation in DMF or NMP solution at room temperature now provides arylzinc sulfonates, which undergo typical catalytic cross-coupling or electrophilic substitution reactions.

Mechanism and selectivity in nickel-catalyzed cross-electrophile coupling of aryl halides with alkyl halides

The direct cross-coupling of two different electrophiles, such as an aryl halide with an alkyl halide, offers many advantages over conventional cross-coupling methods that require a carbon nucleophile. Despite its promise as a versatile synthetic strategy, a limited understanding of the mechanism and origin of cross selectivity has hindered progress in reaction development and design. Herein, we shed light on the mechanism for the nickel-catalyzed cross-electrophile coupling of aryl halides with alkyl halides and demonstrate that the selectivity arises from an unusual catalytic cycle that combines both polar and radical steps to form the new C-C bond.

Discovery of selective nonpeptidergic neuropeptide FF2 receptor agonists

We report the discovery and initial characterization of a novel class of selective NPFF2 agonists. HTS screening using R-SAT, a whole cell based functional assay, identified a class of aryliminoguanidines as NPFF1 and NPFF2 ligands. Subsequent optimizatio