25366-24-9Relevant academic research and scientific papers
SPIROCYCLIC PIPERIDINE DERIVATIVES AS TRPM 8 MODULATORS
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Page/Page column 58, (2010/10/03)
The present invention provides Transient Receptor Potential subfamily M, member 8 (TRPM8) modulators of formula (I). In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPM8.
A new convenient way to synthesize 1,3,4-thiadiazol-2-yl urea derivatives under microwave irradiation
Li, Kejian,Chen, Wenbin
, p. 621 - 629 (2008/12/22)
A simple and efficient method was developed for the synthesis of 1-(substituted)-3-(5-(substituted)-1,3,4-thiadiazol-2-yl) ureas from heterocyclic amino compounds and phenyl-5-(pyridine-3-yl)-1,3,4-thiadiazol-2- ylcarbamate(2) or phenyl-5-(trifluoro-methyl)-1,3,4-thiadiazol-2-ylcarbamate(5) under solvent conditions using microwave irradiation. The products were obtained in satisfactory yield as we expected. The reactions can be realized by conventional heating, but we find that the condition of microwave is better according to the reaction time. New J-(substituted)-3-(5-(substituted)-1,3,4- thiadiazol-2-yl) urea derivatives are reported. The products were characterized by 1H NMR, ESI-MS, and Elemental analysis. The crystal structure of compound 6h was determined by X-ray single crystal diffraction.
HETEROCYCLIC COMPOUNDS AS CCR2B ANTAGONISTS
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Page/Page column 206, (2008/06/13)
Compounds of formula (I) Q-L-W-C(=X)-Z-P wherein Q is an amine of the formula-N (R1)(R2); L is an alkyl or heterocyclyl-alkyl linker; W is a 6-or 7-membered aliphatic ring comprising ring atoms Y1 and Y2 which are linked to groups L and C(X) respectively and Y1 and Y2 are independently selected from N and C; X is O, N, N-CN or S; Z is NR 3; P is an optionally substituted monocyclic or bicyclic aryl or heteroaryl group; and pharmaceutically acceptable salts or solvates thereof, are useful in the treatment of C-C chemokine mediated conditions.
Method of controlling aquatic weeds
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, (2008/06/13)
A method of controlling aquatic weeds which comprises adding to a body of water containing the aquatic weeds a substituted 1-thiadiazolyl-3-arylurea in sufficient quantity to kill the weeds.
