253662-96-3Relevant articles and documents
A direct and selective syntheses of α,α-dichloro-and α-chloro-ethyl ketones by the reaction of alkyl carboxylates with 1,1-dichloroethyllithium
Shiina, Isamu,Imai, Yumiko,Kagayama, Akifumi,Mukaiyama, Teruaki
, p. 190 - 191 (2000)
1,1-Dichloroethyllithium (5), generated by treating 1,1-dichloroethane (4) with lithium diisopropylamide (LDA) or n-butyllithium, reacted with alkyl carboxylates to afford the corresponding α,α-dichloro-or α-monochloro-ethyl ketones selectively in good to
An effective method for the preparation of optically active polyoxy 8-membered ring enone corresponding to the B ring of taxol
Shiina, Isamu,Shibata, Jun,Imai, Yumiko,Ibuka, Ryoutarou,Fujisawa, Hidehiko,Hachiya, Iwao,Mukaiyama, Teruaki
, p. 1145 - 1146 (2007/10/03)
An effective method for the preparation of 8-membered ring enone 1 in sufficient quantities was developed. First, optically active trialkoxyaldehyde 3 was prepared by diastereoselective dihydroxylation of olefin 7 derived from D-pantolactone. Secondly, 8-