253686-24-7

Basic information

• Product Name: Pyridine, 2-chloro-5-(fluoromethyl)- (9CI)
• Synonyms: Pyridine, 2-chloro-5-(fluoromethyl)- (9CI)
• CAS NO: 253686-24-7
• Molecular Formula: C6H5ClFN
• Molecular Weight: 145.5620032
• Product Categories: PYRIDINE
• Mol File: 253686-24-7.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Pyridine, 2-chloro-5-(fluoromethyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 2-chloro-5-(fluoromethyl)- (9CI)(253686-24-7)
• EPA Substance Registry System: Pyridine, 2-chloro-5-(fluoromethyl)- (9CI)(253686-24-7)

Safety Data

• Hazardous Substances Data: 253686-24-7(Hazardous Substances Data)

Upstream product

• 21543-49-7 2-Chloro-5-hydroxymethylpyridine 
• 5326-23-8 6-Chloro-3-pyridinecarboxylic acid 
• 133457-49-5 6-chloro-α-methanesulfonyloxy-3-picoline 

Relevant articles and documents

An efficient synthesis of (fluoromethyl)pyridylamines for labeling with fluorine-18

We have described a two-step method for the preparation of (fluoromethyl)pyridyl-substituted amines. The sequence involves fluoride ion displacement of methanesulfonates (mesylates) of 6-chloro-α-hydroxy-2- and - 3-picolines, followed by arylation of the amine by chloropicoline. We have called this sequence fluorination-N-arylation. 1-Phenylpiperazine has been used as a model amine. Two key precursors for this sequence are the mesylates of 6-chloro-α-hydroxy-2- and -3-picolines. The former was synthesized in four steps from 6-chloro-2-picoline in 78% yield and the latter in three steps from 6-chloronicotinic acid in 53% yield. This fluorination-N-arylation sequence is sufficiently rapid and efficient for the preparation of a variety of aryl-substituted amine compounds labeled with the short half-life (t( 1/2 ) = 110 min) positron-emitting radionuclide fluorine-18.