25373-43-7

Basic information

• Product Name: 1-(2,2-diethoxyethyl)-3-phenylthiourea
• CAS NO: 25373-43-7
• Molecular Formula: C₁₃H₂₀N₂O₂S
• Molecular Weight: 268.3751
• Mol File: 25373-43-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 362.4°C at 760 mmHg
• Flash Point: 173°C
• Density: 1.142g/cm³
• Vapor Pressure: 1.93E-05mmHg at 25°C
• Refractive Index: 1.578
• CAS DataBase Reference: 1-(2,2-diethoxyethyl)-3-phenylthiourea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,2-diethoxyethyl)-3-phenylthiourea(25373-43-7)
• EPA Substance Registry System: 1-(2,2-diethoxyethyl)-3-phenylthiourea(25373-43-7)

Safety Data

• Hazardous Substances Data: 25373-43-7(Hazardous Substances Data)

Usage

General Description

1-(2,2-diethoxyethyl)-3-phenylthiourea is a chemical compound consisting of a thiourea group attached to a phenyl group and a diethoxyethyl group. It is commonly used as a starting material in organic synthesis and is known for its applications in the field of chemistry and pharmacology. It is often utilized as a reagent for the synthesis of various pharmaceuticals and agrochemicals. 1-(2,2-diethoxyethyl)-3-phenylthiourea has properties that make it suitable for use in various industrial processes, and its structure makes it a valuable building block for the creation of more complex compounds. Additionally, its potential pharmacological activities make it an important compound for research and development in the pharmaceutical industry.

Upstream product

• 103-72-0 phenyl isothiocyanate 
• 645-36-3 2,2-diethoxy-ethanamine 
• 7782-77-6 cis-nitrous acid 
• 13733-17-0 isothiocyanoacetaldehyde diethyl acetal 
• 62-53-3 aniline 

Downstream Products

• 17452-09-4 2-mercapto-1-phenylimidazole 
• 123823-57-4 2-[(2-dimethylamino)benzylthio]-1-phenylimidazole 

Relevant articles and documents

Method for preparing cyclic thiourea compound

The method comprises the following steps: suspending metal hydride in anhydrous THF, dropwise adding ring thiourea in the stirring process, stirring at room temperature after completion of stirring, stirring at room temperature, TLC monitoring reaction co

2-[(2-Aminobenzyl)sulfinyl]-1-(2-pyridyl)-1,4,5,6- tetrahydrocyclopent[d]imidazoles as a novel class of gastric H+/K+-ATPase inhibitors

Substituted 2-sulfinylimidazoles were synthesized and investigated as potential inhibitors of gastric H+/K+-ATPase. The 4,5-unsubstituted imidazole series 6-11 and the 1,4,5,6-tetrahydrocyclopent[d]imidazole series 12 were found to be potent inhibitors of the acid secretory enzyme H+/K+- ATPase. Structure-activity relationships indicate that the substitution of 2- pyridyl groups at the 1-position of the imidazole moiety combined with (2- aminobenzyl)sulfinyl groups at the 2-position leads to highly active compounds with a favorable chemical stability. Other substitution patterns in the imidazole moiety result in reducing biological activities. 2-[(2- Aminobenzyl)sulfinyl]-1-[2-(3-methylpyridyl)]-1,4,5,6- tetrahydrocyclopent[d]imidazole (12h, T-776) was selected for further development as a potential clinical candidate. Extensive study on the acid degradation of 12h indicates a mechanism of action different from that of omeprazole, the first H+/K+-ATPase inhibitor introduced to the market.