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Usage

Uses

Used in Pharmaceutical Industry:
ZYGOSPORIN F is used as an antimicrobial agent for its potent antibacterial and antifungal properties, disrupting cell wall formation and membrane integrity in target microorganisms, thereby inhibiting their growth and proliferation.
Used in Anticancer Applications:
ZYGOSPORIN F is used as an anticancer agent for its ability to induce apoptosis and inhibit cell proliferation in several cancer cell lines, offering potential therapeutic benefits in the treatment of various types of cancer.
Used in Drug Development:
ZYGOSPORIN F is used as a lead compound in drug development for its diverse biological activities, including antimicrobial and anticancer properties, providing a foundation for the discovery of novel therapeutic agents with improved efficacy and reduced side effects.

Upstream product

• 22144-77-0 cytochalasin D 
• 108-24-7 acetic anhydride 
• 83071-33-4 17,17O-Dihydro-17,18O-isopropyliden-cytochalasin D 
• 83071-45-8 7-O-Acetyl-17,17O-dihydrocytochalasin D 
• 83114-67-4 17,17O-Dihydrocytochalasin D 
• 164410-42-8 2-N,7-O-diacetylcytochalasin D 
• 83071-32-3 7-O-Acetyl-17,17O-dihydro-17,18O-isopropyliden-cytochalasin D 

Downstream Products

• 83071-45-8 7-O-Acetyl-17,17O-dihydrocytochalasin D 
• 83095-34-5 17,17O-Dihydro-17,18O-isopropyliden-21-O-desacetylcytochalasin D 
• 83071-31-2 17,17O-Dihydro-17,18O-isopropyliden-21-O-dehydroisocytochalasin D 
• 83085-09-0 17,17O-Dihydro-17,18O-isopropyliden-isocytochalasin D 
• 83071-50-5 17,18-Seco-7-O-acetyl-18,18O-didehydrocytochalasin-D 
• 83071-51-6 17,18-Seco-7-O-acetyl-18,18O-didehydro-17-desoxo-17-(cytochalasin-D)saeure 
• 83071-32-3 7-O-Acetyl-17,17O-dihydro-17,18O-isopropyliden-cytochalasin D 

Relevant academic research and scientific papers

Zygosporin D and two new cytochalasins produced by the fungus Metarrhizium anisopliae

Zygosporin D (3) and two new cytochalasins (4 and 5) were isolated from the culture filtrate of the fungus Metarrhizium anisopliae and characterized on the basis of their spectral data and chemical conversions. The new cytochalasins, 4 and 5, were determi

22. Unprecedented ring contractions in cytochalasans: Formation of [10]cytochalasans and a cyclohepta[4,5]benz[1,2-d]isoindole derivative

A series of transformations of cytochalasin D (1; zygosporin A) was carried out. After treatment of the diol 7 with mesyl chloride and pyridine, and subsequent chromatography on silica gel, the 17-acetyl derivatives 12 and 13, the first members of the hitherto unknown [10]cytochalasans, were obtained. The alcohol 8 was converted to the chlorosulfinate 18 under the same conditions. Replacement of pyridine by triethylamine in the mesylation reaction led to the cyclohepta[4,5]benz[1,2-d]isoindole derivative 20, also representing a novel ring system.