83071-45-8

Upstream product

• 83071-32-3 7-O-Acetyl-17,17O-dihydro-17,18O-isopropyliden-cytochalasin D 
• 83071-33-4 17,17O-Dihydro-17,18O-isopropyliden-cytochalasin D 
• 83114-67-4 17,17O-Dihydrocytochalasin D 
• 22144-77-0 cytochalasin D 
• 164410-42-8 2-N,7-O-diacetylcytochalasin D 
• 25374-68-9 7-O-acetylcytochalasin D 

Downstream Products

• 83071-32-3 7-O-Acetyl-17,17O-dihydro-17,18O-isopropyliden-cytochalasin D 
• 83095-34-5 17,17O-Dihydro-17,18O-isopropyliden-21-O-desacetylcytochalasin D 
• 83071-31-2 17,17O-Dihydro-17,18O-isopropyliden-21-O-dehydroisocytochalasin D 
• 83085-09-0 17,17O-Dihydro-17,18O-isopropyliden-isocytochalasin D 
• 25374-68-9 7-O-acetylcytochalasin D 
• 83071-51-6 17,18-Seco-7-O-acetyl-18,18O-didehydro-17-desoxo-17-(cytochalasin-D)saeure 
• 83071-50-5 17,18-Seco-7-O-acetyl-18,18O-didehydrocytochalasin-D 

Relevant academic research and scientific papers

22. Unprecedented ring contractions in cytochalasans: Formation of [10]cytochalasans and a cyclohepta[4,5]benz[1,2-d]isoindole derivative

A series of transformations of cytochalasin D (1; zygosporin A) was carried out. After treatment of the diol 7 with mesyl chloride and pyridine, and subsequent chromatography on silica gel, the 17-acetyl derivatives 12 and 13, the first members of the hitherto unknown [10]cytochalasans, were obtained. The alcohol 8 was converted to the chlorosulfinate 18 under the same conditions. Replacement of pyridine by triethylamine in the mesylation reaction led to the cyclohepta[4,5]benz[1,2-d]isoindole derivative 20, also representing a novel ring system.