253776-70-4Relevant academic research and scientific papers
Regio- and diastereoselective aldol products through three-component coupling reactions of difiuoroboroxy fischer carbene molybdenum complexes
Barluenga, Jose,Rodriguez, Felix,Fananas, Francisco J.,Rubio, Eduardo
, p. 3084 - 3086 (2007/10/03)
The reaction of difluoroboroxy Fischer carbene complexes, vinyl ketones, and aldehydes leads to the regioselective formation of aldol-like products (see reaction scheme). The reaction also shows a high degree of diastereofacial selectivity when chiral aldehydes are used. These results show that this is a very attractive process since the regioselective formation of aldols from nearly symmetrical ketones still remains an unsolved problem.
