253780-48-2

Upstream product

• 143-27-1 hexadecylamine 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 63-91-2 L-phenylalanine 

Downstream Products

• 168071-28-1 (S)-2-amino-N-hexadecyl-3-phenylpropanamide 
• 1467045-62-0 C₄₀H₆₀N₅O₃⁽¹⁺⁾*Cl^(1-) 
• 1467045-57-3 C₃₁H₅₁N₄O₂⁽¹⁺⁾*Cl^(1-) 

Relevant academic research and scientific papers

Antimicrobial and antitumor activity of peptidomimetics synthesized from amino acids

Thirteen cationic peptidomimetics derived from amino acids bearing an alkyl or ethynylphenyl moiety that mimic the structure of cationic antibacterial peptides were designed and synthesized using a simple coupling reaction of an amino acid with a substitu

Carbon-Nanotube-Mediated Electrochemical Transition in a Redox-Active Supramolecular Hydrogel Derived from Viologen and an l -Alanine-Based Amphiphile

A two-component hydrogelator (16-A)2-V2+, comprising an l-alanine-based amphiphile (16-A) and a redox-active viologen based partner (V2+), is reported. The formation the hydrogel depended, not only on the acid-to-amine stoichiometric ratio, but on the choice of the l-amino acid group and also on the hydrocarbon chain length of the amphiphilic component. The redox responsive property and the electrochemical behavior of this two-component system were further examined by step-wise chemical and electrochemical reduction of the viologen nucleus (V2+/V+ and V+/V0). The half-wave reduction potentials (E1/2) associated with the viologen ring shifted to more negative values with increasing amine component. This indicates that higher extent of salt formation hinders reduction of the viologen moiety. Interestingly, the incorporation of single-walled carbon nanotubes in the electrochemically irreversible hydrogel (16-A)2-V2+ transformed it into a quasi-reversible electrochemical system.

Pristine carbon-nanotube-included supramolecular hydrogels with tunable viscoelastic properties

Research investigations involving pristine carbon nanotubes (CNTs) and their applications in diversified fields have been gathering enormous impetus in recent times. One such emerging domain deals with the hybridization of CNTs within hydrogels to form soft nanocomposites with superior properties. However, till now, reports on the inclusion of pristine CNTs within low-molecular-weight hydrogels are very scarce due to their intrinsic feature of remaining in the bundled state and strong repulsive behavior to the aqueous milieu. Herein, the synthesis of a series of amino acid/dipeptide-based amphiphilic hydrogelators having a quaternary ammonium/imidazolium moiety at the polar head and a C16 hydrocarbon chain as the hydrophobic segment is reported. The synthesized amphiphiles exhibited excellent hydrogelation (minimum gelation concentration (MGC) ≈0.7-5 % w/v) as well as single-walled carbon nanotube (SWNT) dispersion ability in aqueous medium. Interestingly, the dispersed SWNTs were incorporated into the supramolecular hydrogel formed by amphiphiles with an imidazolium moiety at the polar end through complementary cation-π and π-π interactions. More importantly, the newly synthesized hydrogelators were able to accommodate a significantly high amount of pristine SWNTs (2-3.5 % w/v) at their MGCs without affecting the gelating properties. This is the first time that such a huge amount of SWNTs has been successfully incorporated within hydrogels. The efficient inclusion of SWNTs to develop soft nanocomposites was thoroughly investigated by spectroscopic and microscopic methods. Remarkably, the developed nanocomposites showed manifold enhancement (≈85-fold) in their mechanical strength compared with native hydrogel without SWNTs. The viscoelastic properties of these nanocomposites were readily tuned by varying the amount of incorporated CNTs. Tubes included: Amino acid/dipeptide-based amphiphilic hydrogelators with an imidazolium head group incorporate large amounts of single-walled carbon nanotubes (SWNTs) without compromising their intrinsic properties. Remarkable enhancement (ca. 85-fold) in the mechanical rigidity of the resulting soft nanocomposite is observed, which can be modulated by varying the amount of incorporated SWNTs (see figure). Copyright

Refining hydrogelator design: Soft materials with improved gelation ability, biocompatibility and matrix for in situ synthesis of specific shaped GNP

Despite the continuous surge in the development of new supramolecular gels, the prediction of a gelator's structure still remains elusive. It is also imperative to consolidate the existing inventory of gelators and devise ways to make the gels functional.

Amino acid based low-molecular-weight ionogels as efficient dye-adsorbing agents and templates for the synthesis of TiO2 nanoparticles

The gelation of ionic liquids is attracting significant attention because of its large spectrum of applications across different disciplines. These 'green solvents' have been the solution to a number of common problems due to their eco-friendly features. To expand their applications, the gelation of ionic liquids has been achieved by using amino acid-based low-molecularweight compounds. Variation of individual segments in the molecular skeleton of the gelators, which comprise the amino acid and the protecting groups at the N and C termini, led to an understanding of the structure-property correlation of the ionogelation process. An aromatic ring containing amino acid-based molecules protected with a phenyl or cyclohexyl group at the N terminus were efficient in the gelation of ionic liquids. In the case of aliphatic amino acids, gelation was more prominent with a phenyl group as the N-terminal protecting agent. The probable factors responsible for this supramolecular association of the gelators in ionic liquids have been studied with the help of field-emission SEM, 1H NMR, FTIR, and luminescence studies. It is the hydrophilic-lipophilic balance that needs to be optimized for a molecule to induce gelation of the green solvents. Interestingly, to maximize the benefits from using these green solvents, these ionogels have been employed as templates for the synthesis of uniform-sized TiO2 nanoparticles (25-30 nm). Furthermore, as a complement to their applications, ionogels serve as efficient adsorbents of both cationic and anionic dyes and were distinctly better relative to their organogel counterparts.

Superior SWNT dispersion by amino acid based amphiphiles: Designing biocompatible cationic nanohybrids

Stable aqueous SWNT dispersion up to 92% was achieved using amino acid based amphiphiles through a structure-property investigation. The nanohybrids showed remarkable serum stability and biocompatibility to mammalian cells.