253863-19-3

Basic information

• Product Name: LL Z1640-2
• Synonyms: C 292;FR148083;L 783279;f 152 A1;(2E,5S,6S,8Z,11S)-5,6,15-trihydroxy-17-methoxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(14),2,8,15,17-pentaene-7,13-dione
• CAS NO: 253863-19-3
• Molecular Formula: C₁₉H₂₂O₇
• Molecular Weight: 362.37378
• Mol File: 253863-19-3.mol
• Article Data: 0

Chemical Properties

• Melting Point: 171-173 °C(Solv: dichloromethane (75-09-2); hexane (110-54-3))
• Boiling Point: 666.8°Cat760mmHg
• Flash Point: 240.2°C
• Appearance: white to off-white/
• Density: 1.27g/cm³
• Storage Temp.: 2-8°C
• Solubility: DMSO: >10mg/mL
• PKA: 7.32±0.70(Predicted)
• CAS DataBase Reference: LL Z1640-2(CAS DataBase Reference)
• NIST Chemistry Reference: LL Z1640-2(253863-19-3)
• EPA Substance Registry System: LL Z1640-2(253863-19-3)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• WGK Germany: 3
• Hazardous Substances Data: 253863-19-3(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 253863-19-3 differently. You can refer to the following data:
1. LL Z1640-2 (5Z-7-oxozeaenol) is a cis-enone resorcylic acid lactone first reported in 1978 and later rediscovered as an irreversible and highly selective TAK 1 inhibitor. TAK1 is a MAPKKK involved in the p38 signalling cascade for pro-inflammation signals such as cytokines. LL Z1640-2 effectively prevents inflammation in animal models.
2. (5Z)-7-Oxozeaenol is a highly potent inhibitor of TAK1, which is a member of the mitogen-acitvated kinase kinase kinase (MAPKKK) family. 5Z-?7-?Oxozeaenol blocked interleukin-?1-?induced activation of TAK1, JNK?/p38 MAPK, IκB kinases, and NF-?κB, resulting in inhibition of cyclooxgenase-?2 production.

Biochem/physiol Actions

The anti-inflammatory effects of 5Z-7-oxozeaenol may affect cardiac hypertrophy.

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