25389-49-5Relevant academic research and scientific papers
One-pot regioselective synthesis of n-benzoyl 2-amino-3,4-dihydro-3-oxo-2h- 1,4-benzothiazi nes
Mabrouk,Elachqar,Alami,Hallaoui,Hajji
experimental part, p. 1249 - 1255 (2011/10/11)
A protocol for regioselective one-pot synthesis of 2-amino-3,4-dihydro-3- oxo-2H-1, 4-benzothiazmes has been developed. Starting from commercially available 2-aminothiophenols a basemediated regioselective S-alkylation took place with methyl α-azido glyci
Synthesis of unnatural amino acids from serine derivatives by β-fragmentation of primary alkoxyl radicals
Boto, Alicia,Gallardo, Juan A.,Hernandez, Dacil,Hernandez, Rosendo
, p. 7260 - 7269 (2008/02/11)
(Chemical Equation Presented) The fragmentation of primary alkoxyl radicals has been scarcely used in synthesis since other competing processes (such as oxidation or hydrogen abstraction) usually predominate. However, when serine derivatives were used as
Reactions of α-Substituted Glycine Derivatives with Stannanes in the Presence of Disulfides
Easton, Christopher J.,Peters, Steven C.
, p. 859 - 868 (2007/10/02)
Reactions of α-bromo-, α-benzoyloxy- and α-methoxy-substituted glycine derivatives with stannanes afforded the corresponding α-centred glycinyl radical, which reacted with di-t-butyl disulfide and diphenyl disulfide by homolytic substitution to give the corresponding α-t-butylthio- and α-phenylthio-substituted glycine derivatives, respectively.The glycinyl radical reacted with dibenzyl disulfide by displacement of benzyl radical to give a mixed disulfide, which was subsequently reduced to the corresponding α-benzylthio-substituted glycine derivative.In related reactions of a cystine derivative the corresponding S-glycinylcysteine derivative was produced, indicating that, while the chemical integrity of disulfide bonds in cystine derivatives is likely to be affected in radical reactions of peptides, the reactions are suitable for exploitation in the synthesis of cross-linked amino acid derivatives.
