25410-93-9Relevant academic research and scientific papers
Syntheses of the marine alkaloids 6-oxofascaplysin, fascaplysin and their derivatives
Zhidkov, Maxim E.,Kantemirov, Alexey V.,Koisevnikov, Alexey V.,Andin, Alexander N.,Kuzmich, Alexandra S.
, p. 708 - 711 (2018)
A simple approach towards the pyrido[1,2-a:3,4-b′]diindole system via the reaction of indigo with methylene active compounds was used for the syntheses of the marine alkaloids 6-oxofascaplysin, fascaplysin, and their derivatives. It was also demonstrated that the reaction with ketones led to indigo decomposition and the formation of isatin derivatives. The derivative of fascaplysin with a phenyl substituent at C-7 demonstrated 2–3 times greater inhibitory activity against selected cancer cell lines than fascaplysin.
