254100-63-5

Upstream product

• 6372-43-6 diisopropylphenylphosphane 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 17586-69-5 Methyl-diisopropyl-phenyl-phosphonium Iodid 
• 254100-73-7 [(1S,2R,4R)-2-(tert-Butyl-dimethyl-silanyloxy)-7,7-dimethyl-bicyclo[2.2.1]hept-1-yl]-methanesulfonyl chloride 
• 36050-92-7 iso-propyl methyl phenylphosphine 
• 254100-59-9 (1S,2R)-O-(tert-butyldimethylsilyl)isobornyl-10-sulfonyl azide 

Downstream Products

• 31253-31-3 (S_P*)-isopropyl(methyl)phenylphosphine oxide 

Relevant academic research and scientific papers

A simple resolution procedure using the Staudinger reaction for the preparation of P-stereogenic phosphine oxides

The resolution of a variety of (±)-P-stereogenic phosphines is achieved by exploiting the Staudinger reaction of a (±)-phosphine with enantiopure (1S,2R)-O-(tert-butyldimethylsilyl)isobornyl-10-sulfonyl azide. The resulting mixtures of diastereomeric phosphinimines are generally separable by fractional crystallization or flash chromatography. Subsequent acid-catalyzed hydrolysis provides the corresponding optically pure phosphine oxides in high yields.

A Novel Resolution Procedure for the Preparation of P-Stereogenic Phosphine Oxides

(Matrix Presented) A new general route for preparing enantiomerically pure P-stereogenic phosphine oxides has been developed by exploiting the Staudinger reaction between racemic tertiary phosphines and an enantiomerically pure organoazide. The resulting