254106-22-4

Basic information

• Product Name: 4-(4-methanesulfonyl-phenyl)-5,5-dimethyl-3-(5-vinyl-pyridin-2-yloxy)-5H-furan-2-one
• CAS NO: 254106-22-4
• Molecular Weight: 385.441
• Mol File: 254106-22-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(4-methanesulfonyl-phenyl)-5,5-dimethyl-3-(5-vinyl-pyridin-2-yloxy)-5H-furan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-methanesulfonyl-phenyl)-5,5-dimethyl-3-(5-vinyl-pyridin-2-yloxy)-5H-furan-2-one(254106-22-4)
• EPA Substance Registry System: 4-(4-methanesulfonyl-phenyl)-5,5-dimethyl-3-(5-vinyl-pyridin-2-yloxy)-5H-furan-2-one(254106-22-4)

Safety Data

• Hazardous Substances Data: 254106-22-4(Hazardous Substances Data)

Upstream product

• 189956-34-1 2-chloroacetoxy-2-methyl-1-(4-(methylsulfonyl)phenyl)propan-1-one 
• 180048-73-1 2-hydroxy-2-methyl-1-(4-(methylsulfonyl)-phenyl)propan-1-one 
• 7486-35-3 tri-n-butyl(vinyl)tin 
• 189954-65-2 3-[(5-bromo-2-pyridinyl)oxy]-5,5-dimethyl-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone 

Relevant articles and documents

Synthesis and biological evaluation of 3-heteroaryloxy-4-phenyl-2(5H)-furanones as selective COX-2 inhibitors

A series of 3-heteroaryloxy-4-phenyl-2-(5H)-furanones were prepared and evaluated for their potency and selectivity as COX-2 inhibitors. This led to the identification of L-778,736 as a potent, orally active and selective inhibitor of the COX-2 enzyme.