189956-34-1Relevant academic research and scientific papers
Synthesis and biological evaluation of 3-heteroaryloxy-4-phenyl-2(5H)-furanones as selective COX-2 inhibitors
Lau, Cheuk K.,Brideau, Christine,Chan, Chi Chung,Charleson, Stella,Cromlish, Wanda A.,Ethier, Diane,Yves Gauthier, Jacques,Gordon, Robert,Guay, Jocelyne,Kargman, Stacia,Li, Chun-Sing,Prasit, Petpiboon,Riendeau, Denis,Therien, Michel,Visco, Denise M.,Xu, Lijing
, p. 3187 - 3192 (1999)
A series of 3-heteroaryloxy-4-phenyl-2-(5H)-furanones were prepared and evaluated for their potency and selectivity as COX-2 inhibitors. This led to the identification of L-778,736 as a potent, orally active and selective inhibitor of the COX-2 enzyme.
